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糖尿病慢性骨骼肌损害发病机制的研究进展
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Abstract:
骨骼肌是胰岛素刺激下葡萄糖摄取的核心代谢组织，负责人体高达85%的葡萄糖代谢，同时又是胰岛素抵抗的主要部位。当机体长期处于高血糖时，肌肉会受到一定程度的损害，称为肌病，而肌肉的损害反过来又会加重胰岛素的抵抗，如此形成恶性循环。糖尿病患者骨骼肌损害隐匿，易被忽视，但却对葡萄糖代谢有着重要影响，本文就糖尿病骨骼肌损害发病机制的研究进展进行综述，为糖尿病患者血糖控制及预防相关并发症提供依据。
Skeletal muscle is the core metabolic tissue of glucose uptake stimulated by insulin, which is re-sponsible for up to 85% of glucose metabolism in the human body, and is also the main part of insu-lin resistance. When the body is in hyperglycemia for a long time, muscle will be damaged to a cer-tain extent, which is called myopathy, and muscle damage in turn will aggravate insulin resistance, thus forming a vicious circle. Skeletal muscle damage in patients is hidden and easy to be ignored, but it has an important impact on glucose metabolism. This paper reviews progress on the patho-genesis of skeletal muscle damage in the diabetes mellitus, so as to provide basis for blood glucose control and prevention of related complications in patients with diabetes.
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