%0 Journal Article
%T 糖尿病慢性骨骼肌损害发病机制的研究进展<br>Study Progress on the Pathogenesis of Skeletal Muscle Damage in the Diabetes Mellitus
%A 方雪
%A 康彧
%J Advances in Clinical Medicine
%P 8859-8865
%@ 2161-8720
%D 2023
%I Hans Publishing
%R 10.12677/ACM.2023.1361238
%X 骨骼肌是胰岛素刺激下葡萄糖摄取的核心代谢组织，负责人体高达85%的葡萄糖代谢，同时又是胰岛素抵抗的主要部位。当机体长期处于高血糖时，肌肉会受到一定程度的损害，称为肌病，而肌肉的损害反过来又会加重胰岛素的抵抗，如此形成恶性循环。糖尿病患者骨骼肌损害隐匿，易被忽视，但却对葡萄糖代谢有着重要影响，本文就糖尿病骨骼肌损害发病机制的研究进展进行综述，为糖尿病患者血糖控制及预防相关并发症提供依据。<br />
Skeletal muscle is the core metabolic tissue of glucose uptake stimulated by insulin, which is re-sponsible for up to 85% of glucose metabolism in the human body, and is also the main part of insu-lin resistance. When the body is in hyperglycemia for a long time, muscle will be damaged to a cer-tain extent, which is called myopathy, and muscle damage in turn will aggravate insulin resistance, thus forming a vicious circle. Skeletal muscle damage in patients is hidden and easy to be ignored, but it has an important impact on glucose metabolism. This paper reviews progress on the patho-genesis of skeletal muscle damage in the diabetes mellitus, so as to provide basis for blood glucose control and prevention of related complications in patients with diabetes.
%K 糖尿病，骨骼肌，肌病<br>Diabetes Mellitus
%K Skeletal Muscle
%K Myopathy
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=66646