Variable
Common Immune Deficiency (VCID) is a very heterogeneous condition both
clinically and immunologically. It is a group of molecular abnormalities responsible for a defect in antibody
production leading to hypogammaglobulinemia often associated with
autoimmune and/or lymphoproliferative manifestations.Late Onset Combined Immune Deficiency (LOCID) is a
type of Variable Common Immune Deficiency (VCID) defined by a defect in
antibody production (IgG and IgA ± IgM
type), profound CD4 T-cell lymphopenia and frequent opportunistic infections.LOCID has been considered as
a distinct entity from VCID due to its particular clinical and immunological
profile.
References
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[2]
Chapel, H. and Cunningham-Rundles, C. (1999) Update in Understanding Common Variable Immunodeficiency Disorders (CVIDs) and the Management of Patients with these Conditions. British Journal of Haematology, 145, 709-727.
https://doi.org/10.1111/j.1365-2141.2009.07669.x
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https://doi.org/10.1182/blood-2007-11-124545
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[6]
Steuer, A., Franz, A., Furr, P.M., Taylor-Robinson, D., Webster, A.D. and Hughes, G.R. (1996) Common Variable Immunodeficiency Presenting as a Mycoplasma Hominis Septic Arthritis. Journal of Infection, 33, 235-237.
https://doi.org/10.1016/S0163-4453(96)92441-X
[7]
Bonilla, H.F., Chenoweth, C.E., Tully, J.G., Blythe, L.K., Robertson, J.A., Ognenovski, V.M., et al. (1997) Mycoplasma Felis Septic Arthritis in a Patient with Hypogammaglobulinemia. Clinical Infectious Diseases, 24, 222-225.
https://doi.org/10.1093/clinids/24.2.222
Hermaszewski, R.A. and Webster, A.D. (1993) Primary Hypogammaglobulinaemia: A Survey of Clinical Manifestations and Complications. Quarterly Journal of Medicine, 86, 31-42.
[10]
Cunningham-Rundles, C. and Bodian, C. (1999) Common Variable Immunodeficiency: Clinical and Immunological Features of 248 Patients. Clinical Immunology, 92, 34-48. https://doi.org/10.1006/clim.1999.4725
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Pavic, M., Sève, P., Malcus, C., Sarrot-Reynauld, F., Peyramond, D., Debourdeau, P., et al. (2005) Variable Common Immune Deficiency with Autoimmune Manifestations: Study of Nine Observations; Interest of Specific Immunophenotyping of Circulating B-Lymphocytes in Seven Patients. La Revue de Médecine Interne, 26, 95-102. https://doi.org/10.1016/j.revmed.2004.11.001
[12]
Sander, C.A., Medeiros, L.J., Weiss, L.M., Yano, T., Sneller, M.C. and Jaffe, E.S. (1992) Lymphoproliferative Lesions in PATIENTS with Common Variable Immunodeficiency Syndrome. The American Journal of Surgical Pathology, 16, 1170-1182. https://doi.org/10.1097/00000478-199212000-00004
[13]
Talibi Alaoui, Z. (2017) Les Deficit Immunitaires Primitifs chez L’Enfant. Ph.D. Thesis, University of Cadi Ayyad, Marrakech.
