|
|
TyG指数与2型糖尿病视网膜病变的相关性分析
|
Abstract:
糖尿病视网膜病变是糖尿病常见的微血管并发症，其流行比例逐年增加，给医疗卫生系统带来了沉重的负担。其发病机制复杂多样，目前尚未完全解释清楚。本文通过回顾近几年空腹甘油三酯–葡萄糖糖(TyG)指数与胰岛素抵抗相关的文献，来探讨TyG指数与2型糖尿病视网膜病变的关系。
Diabetes retinopathy is a common microvascular complication of diabetes, and its prevalence rate has increased year by year, which has brought a heavy burden to the medical and health system. Its pathogenesis is complex and diverse, and has not yet been fully explained. This article reviews the literature on the relationship between fasting triglyceride glucose (TyG) index and insulin re-sistance in recent years to explore the relationship between TyG index and type 2 diabetes reti-nopathy.
| [1] | Lin, X., Xu, Y., Pan, X., et al. (2020) Global, Regional and National Burden and Trend of Diabetes in 195 Countries and Territories: An Analysis from 1990 to 2025. Scientific Reports, 10, Article No. 14790.
https://doi.org/10.1038/s41598-020-71908-9 |
| [2] | Saeedi, P., Petersohn, I., Salpea, P., et al. (2019) Global and Re-gional Diabetes Prevalence Estimates for 2019 and Projections for 2030 and 2045: Results from the International Diabe-tes Federation Diabetes Atlas, 9th Edition. Diabetes Research and Clinical Practice, 157, Article ID: 107843. https://doi.org/10.1016/j.diabres.2019.107843 |
| [3] | 童南伟, 邢小平. 内科学: 内分泌科分册[M]. 北京: 人民卫生出版社, 2015. |
| [4] | Cheung, N., Mitchell, P. and Wong, T.Y. (2010) Diabetic Retinopathy. The Lancet, 376, 124-136.
https://doi.org/10.1016/S0140-6736(09)62124-3 |
| [5] | Srf, A., Prrab, B., Psrc, D., et al. (2017) Global Causes of Blindness and Distance Vision Impairment 1990-2020: A Systematic Review and Meta-Analysis. The Lancet Global Health, 5, e1221-e1234. |
| [6] | Wong, T.Y., Sun, J., Kawasaki, R., et al. (2018) Guidelines on Diabetic Eye Care: The In-ternational Council of Ophthalmology Recommendations for Screening, Follow-Up, Referral, and Treatment Based on Resource Settings. Ophthalmology, 125, 1608-1622. https://doi.org/10.1016/j.ophtha.2018.04.007 |
| [7] | Stitt, A.W., Curtis, T.M., Chen, M., et al. (2016) The Progress in Understanding and Treatment of Diabetic Retinopathy. Progress in Retinal and Eye Research, 51, 156-186. https://doi.org/10.1016/j.preteyeres.2015.08.001 |
| [8] | Minassian, D.C., Reidy, A., Lightstone, A. and Desai, P. (2011) Modelling the Prevalence of Age-Related Macular Degeneration (2010-2020) in the UK: Expected Impact of Anti-Vascular Endothelial Growth Factor (VEGF) Therapy. British Journal of Ophthalmology, 95, 1433-1436. https://doi.org/10.1136/bjo.2010.195370 |
| [9] | Kelley, D.E. (2002) Skeletal Muscle Triglycerides: An Aspect of Regional Adiposity and Insulin Resistance. Annals of the New York Academy of Sci-ences, 967, 135-145. https://doi.org/10.1111/j.1749-6632.2002.tb04271.x |
| [10] | Jin, J.L., Cao, Y.X., Wu, L.G., et al. (2018) Triglyceride Glucose Index for Predicting Cardiovascular Outcomes in Patients with Coronary Artery Disease. The Journal of Thoracic Disease, 10, 6137-6146.
https://doi.org/10.21037/jtd.2018.10.79 |
| [11] | Gutch, M., Kumar, S., Razi, S.M., Gupta, K.K. and Gupta, A. (2015) Assessment of Insulin Sensitivity/Resistance. Indian Journal of Endocrinology and Metabolism, 19, 160-164. https://doi.org/10.4103/2230-8210.146874 |
| [12] | Antoniolli, L.P., Nedel, B.L., Pazinato, T.C., de Andrade Mesquita, L. and Gerchman, F. (2018) Accuracy of Insulin Resistance Indices for Metabolic Syndrome: A Cross-Sectional Study in Adults. Diabetology & Metabolic Syndrome, 10, Article No. 65. https://doi.org/10.1186/s13098-018-0365-y |
| [13] | Guerrero-Romero, F., Simental-Mendía, L.E., González-Ortiz, M., et al. (2010) The Product of Triglycerides and Glucose, a Simple Measure of Insulin Sensitivity. Comparison with the Euglycemic-Hyperinsulinemic Clamp. The Journal of Clinical Endocrinology & Metabolism, 95, 3347-3351. https://doi.org/10.1210/jc.2010-0288 |
| [14] | Thai, P.V., Tien, H.A., Van Minh, H. and Valensi, P. (2020) Triglycer-ide Glucose Index for the Detection of Asymptomatic Coronary Artery Stenosis in Patients with Type 2 Diabetes. Car-diovascular Diabetology, 19, Article No. 137.
https://doi.org/10.1186/s12933-020-01108-2 |
| [15] | Vasques, A.C., Novaes, F.S., de Oliveira Mda, S., et al. (2011) TyG Index Performs Better than HOMA in a Brazilian Population: A Hyperglycemic Clamp Validated Study. Diabetes Research and Clinical Practice, 93, e98-e100.
https://doi.org/10.1016/j.diabres.2011.05.030 |
| [16] | Luo, P., Cao, Y., Li, P., et al. (2022) TyG Index Performs Better than HOMA-IR in Chinese Type 2 Diabetes Mellitus with a BMI < 35 kg/m2: A Hyperglycemic Clamp Validated Study. Medicina, 58, Article 876.
https://doi.org/10.3390/medicina58070876 |
| [17] | Kahui, P., Woo, A.C., Bae, L.S., Kang, S., Nam, J.S., Lee, B.K., Kim, J.H. and Park, J.S. (2019) Elevated TyG Index Predicts Progression of Coronary Artery Calcification. Diabetes Care, 42, 1569-1573.
https://doi.org/10.2337/dc18-1920 |
| [18] | Li, M., Zhan, A., Huang, X., Hu, L., Zhou, W., Wang, T., Zhu, L., Bao, H. and Cheng, X. (2020) Positive Association between Triglyceride Glucose Index and Arterial Stiffness in Hypertensive Patients: the China H-type Hypertension Registry Study. Cardiovascular Diabetology, 19, Article No. 139. https://doi.org/10.1186/s12933-020-01124-2 |
| [19] | Bornfeldt, K. and Tabas, I. (2011) Insulin Resistance, Hypergly-cemia, and Atherosclerosis. Cell Metabolism, 14, 575-585.
https://doi.org/10.1016/j.cmet.2011.07.015 |
| [20] | Betts-Obregon, B.S., Mondragon, A.A., Mendiola, A.S., LeBaron, R.G., Asmis, R., Zou, T., Gonzalez-Fernandez, F. and Tsin, A.T. (2016) TGFβ Induces BIGH3 Expression and Human Retinal Pericyte Apoptosis: A Novel Pathway of Diabetic Retinopathy. Eye, 30, 1639-1647. . |
| [21] | Palombo, C. and Kozakova, M. (2016) Arterial Stiffness, Atherosclerosis and Cardiovascular Risk: Pathophysiologic Mechanisms and Emerging Clinical Indications. Vascular Pharmacology, 77, 1-7.
https://doi.org/10.1016/j.vph.2015.11.083 |
| [22] | Virani, S.S., Alonso, A., Benjamin, E.J., et al. (2020) Heart Disease and Stroke Statistics—2020 Update: A Report from the American Heart Association. Circulation, 141, e139-e596. https://doi.org/10.1161/CIR.0000000000000757 |
| [23] | Jellinger, P.S., Handelsman, Y., Rosenblit, P.D., et al. (2017) American Association of Clinical Endocrinologists and American College of Endocrinology Guidelines for Management of Dyslipidemia and Prevention of Cardiovascular Disease. Endocrine Practice, 23, 1-87. |
| [24] | Xu, Y., Wang, L., He, J., et al. (2013) Prevalence and Control of Diabetes in Chinese Adults. JAMA, 310, 948-959.
https://doi.org/10.1001/jama.2013.168118 |
| [25] | Vlachopoulos, C., Aznaouridis, K., Terentes-Printzios, D., Ioakeimidis, N. and Stefanadis, C. (2012) Prediction of Cardiovascular Events and All-Cause Mortality with Brachi-al-Ankle Elasticity Index: A Systematic Review and Meta-Analysis. Hypertension, 60, 556-562. https://doi.org/10.1161/HYPERTENSIONAHA.112.194779 |
| [26] | Kim, W.J., Park, C., Park, S.E., et al. (2012) The Association between Regional Arterial Stiffness and Diabetic Retinopathy in type 2 Diabetes. Atherosclerosis, 225, 237-241. https://doi.org/10.1016/j.atherosclerosis.2012.08.034 |
| [27] | Yuanyuan, Z., Panpan, H., Youbao, L., et al. (2019) Positive Association between Baseline Brachial-Ankle Pulse Wave Velocity and the Risk of New-Onset Diabetes in Hypertensive Patients. Cardiovascular Diabetology, 18, Article No. 111. https://doi.org/10.1186/s12933-019-0915-0 |
| [28] | Laakso, M. and Kuusisto, J. (2014) Insulin Resistance and Hy-perglycaemia in Cardiovascular Disease Development. Nature Reviews Endocrinology, 10, 293-302. https://doi.org/10.1038/nrendo.2014.29 |
| [29] | Srinivasan, S., Singh, P., Kulothungan, V., Sharma, T. and Raman, R. (2021) Relationship between Triglyceride Glucose Index, Retinopathy and Nephropathy in Type 2 Diabetes. Endocri-nology, Diabetes and Metabolism Journal, 4, e00151. https://doi.org/10.1002/edm2.151 |
| [30] | Chiu, H., Tsai, H.J., Huang, J.C., et al. (2020) Associations between Triglyceride-Glucose Index and Micro- and Macro-Angiopathies in Type 2 Diabetes Mellitus. Nutrients, 12, Article 328. https://doi.org/10.3390/nu12020328 |
| [31] | Yao, L., Wang, X., Zhong, Y., et al. (2021) The Triglyceride-Glucose Index Is Associated with Diabetic Retinopathy in Chinese Patients with Type 2 Diabetes: A Hospital-Based, Nested, Case-Control Study. Diabetes, Metabolic Syndrome and Obesity, 14, 1547-1555. https://doi.org/10.2147/DMSO.S294408 |
| [32] | Kumari, N., Yu, A.K.C., Keven, A., Subramaniam, T., Fang, S.C. and Chi, L.S. (2023) Association of Triglyceride Glucose Index with Prevalence and Incidence of Diabetic Retinopathy in a Singaporean Population. Clinical Ophthalmology, 17, 445-454. https://doi.org/10.2147/OPTH.S382336 |
| [33] | Unger, G., Benozzi, S.F., Perruzza, F. and Pennacchiotti, G.L. (2014) Triglycerides and Glucose Index: A Useful Indicator of Insulin Resistance. Endocrinología y Nutrición, 61, 533-540. https://doi.org/10.1016/j.endonu.2014.06.009 |
| [34] | Kolluru, G.K., Bir, S.C. and Kevil, C.G. (2012) Endothelial Dysfunction and Diabetes: Effects on Angiogenesis, Vascular Remodeling, and Wound Healing. International Journal of Vascular Medicine, 2012, Article ID: 918267.
https://doi.org/10.1155/2012/918267 |
| [35] | Kearney, K., Tomlinson, D., Smith, K. and Ajjan, R. (2017) Hypofibri-nolysis in Diabetes: A Therapeutic Target for the Reduction of Cardiovascular Risk. Cardiovascular Diabetology, 16, Article No. 34.
https://doi.org/10.1186/s12933-017-0515-9 |
| [36] | Wong, T.Y., Cheung, C.M., Larsen, M., Sharma, S. and Simó, R. (2016) Diabetic Retinopathy. Nature Reviews Disease Primers, 2, Article No. 16012. https://doi.org/10.1038/nrdp.2016.12 |
| [37] | Yau, J.W., Rogers, S.L., Kawasaki, R., et al. (2012) Global Prevalence and Major Risk Factors of Diabetic Retinopathy. Diabetes Care, 35, 556-564. https://doi.org/10.2337/dc11-1909 |
