High Feed efficiency (FE) in growing heifers has economic importance in dairy,
but remains less understood in buffaloes. Feed conversion efficiency is defined
as dry matter intake (DMI) per unit body weight gain and is determined as
residual feed intake (RFI), i.e., the difference between actual and predicted feed intake
to gain unit body weight during a feed trial run for 78 days under control
feeding. A large variation was identified ranging between -0.42 to 0.35 in
growing buffalo heifers (n=40) of age
between 11 to 15 months. An average daily weight gain (ADG) varied between
382.0 and 807.6 g/day when compared with the control-fed heifers at an organized buffalo farm. The whole blood transcriptome data obtained from the
selected growing heifers from extremes of estimated high and low RFI efficiency
were compared with the reference assembly generated from the transcriptome of
multiparous buffaloes (n = 16) of diverse age of maturity, period of regaining
post partum cyclicity and level of milk production.
Differentially expressed genes (DEGs) were identified using the reference genome of Mediterranean water buffalo. GO:
terms (Padj<0.05, FDR<0.05)
enriched by annotated DEGs and biological pathways in gene network for RFI
efficiency trait were identified. GO:terms
specific to pre-transcriptional
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