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精神分裂症的治疗及与糖尿病关系的研究进展
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Abstract:
精神分裂症患病人数逐年增加，糖尿病患病率逐年攀升，这两种疾病之间存在着一定的联系。精神分裂症患者受基因、内分泌紊乱、抗精神病药物使用、炎性因子及生活习惯等因素影响，容易共病糖尿病。本文将从流行病学、与基因的关联、与炎性因子的关系、与内分泌的关系等方面进行介绍。
The number of patients with schizophrenia increased year by year, and the prevalence of diabetes increased year by year. There is a link between the two diseases. Schizophrenia patients are affect-ed by genes, endocrine disorder, antipsychotic drug use, inflammatory factors, lifestyle habits and other factors, prone to comorbidity diabetes. This article will be introduced from the epidemiology, the correlation with genes, the relationship with inflammatory factors, and the relationship with endocrinology.
| [1] | 郝伟, 陆林. 精神病学[M]. 北京: 人民卫生出版社, 2018. |
| [2] | He, H.R., Liu, Q.Q., Li, N., et al. (2020) Trends in the Incidence and DALYs of Schizophrenia at the Global, Regional and National Levels: Results from the Global Burden of Disease Study 2017. Epidemiology and Psychiatric Sciences, 29, E91. https://doi.org/10.1017/S2045796019000891 |
| [3] | International Diabetes Federation (2021) IDF Diabetes Atlas. 10th Edition. International Diabetes Federation. |
| [4] | 中华医学会糖尿病学分会. 中国2型糖尿病防治指南(2020年版) [J]. 国际内分泌代谢杂志, 2021, 41(5): 482-548. |
| [5] | 张淑芬, 陆艳, 兰光华, 袁勇贵. 精神分裂症与糖尿病共病患者认知功能的对照研究[J]. 临床精神医学杂志, 2018, 28(4): 276. |
| [6] | Dasgupta, A., Singh, O. P., Rout, J. K., Saha, T., & Mandal, S. (2010) IInsulin Resistance and Metabolic Profile in Antipsychotic Na？ve Schizophrenia Pa-tients. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 34, 1202-1207. https://doi.org/10.1016/j.pnpbp.2010.06.011 |
| [7] | 郭向晴, 赵静, 易正辉, 等. 精神分裂症并发2型糖尿病与五羟色胺2C受体基因多态性的关联性[J]. 复旦学报(医学版), 2021, 48(1): 1-7. |
| [8] | 汪晓晖, 郭向晴, 鲍晨曦, 等. 精神分裂症患者5-羟色胺2C受体基因多态性与2型糖尿病共病的关联研究[J]. 临床精神医学杂志, 2017, 27(3): 153-156. |
| [9] | 李园园, 王周烨, 禹顺英, 等. 精神分裂症伴发2型糖尿病与烟碱型乙酰胆碱受体基因多态性关联研究[J]. 中国神经精神疾病杂志, 2017, 43(8): 464-469. |
| [10] | 王嘉欣. 中国汉族人群精神分裂症和2型糖尿病共享易感基因及其致病机制研究[D]: [博士学位论文]. 长春: 吉林大学, 2015. |
| [11] | 张六平, 李文杰, 易正辉, 等. 精神分裂症伴发2型糖尿病与色氨酸羟化酶基因多态性关联研究[J]. 临床精神医学杂志, 2010, 20(1): 4-6. |
| [12] | Sargazi, S., Nia, M.H., Saravani, R., Shahroudi, M.J., Jahantigh, D., & Shakiba, M. (2020) IGF2BP2 Poly-morphisms as Genetic Biomarkers for Either Schizophrenia or Type 2 Diabetes Mellitus: A Case-Control Study. Gene Reports, 20, Article ID: 100680. https://doi.org/10.1016/j.genrep.2020.100680 |
| [13] | Zhang, X., Hui, L., Liu, Y., et al. (2013) The Type 2 Diabetes Mellitus Susceptibility Gene IGF2BP2 Is Associated with Schizophrenia in a Han Chi-nese Population. The Journal of Clinical Psychiatry, 74, e287-e292.
https://doi.org/10.4088/JCP.12m07846 |
| [14] | 胡佳, 常宁, 赵刘乐, 曹爽. 炎性因子对精神分裂症患者罹患糖尿病相关影响因素的研究进展[J]. 河北医药, 2019, 41(22): 3482-3486+3490. |
| [15] | 张向阳, 周东丰, 沈渔邨, 等. 精神分裂症白细胞介素2、6、8与精神病理的关系[J]. 中国神经精神疾病杂志, 1999(6): 346-348. |
| [16] | 胡佳, 常宁, 曹爽. 血清NF-κB、CRP、IL-6及TNF-α水平与精神分裂症合并2型糖尿病的相关性[J]. 贵州医科大学学报, 2022, 47(10): 1189-1193. |
| [17] | Zhang, Q.T., Hong, W., Li, H.Z., et al. (2017) Increased Ratio of High Sensitivity C-Reactive Protein to Interleukin-10 as a Potential Peripheral Biomarker of Schizophrenia and Aggression. International Journal of Psychophysiology, 114, 9-15. https://doi.org/10.1016/j.ijpsycho.2017.02.001 |
| [18] | 刘芳. 2型糖尿病患者下丘脑-垂体-肾上腺轴功能变化的临床意义[J]. 中国医学工程, 2016, 24(12): 52-53. |
| [19] | Bradley, A.J. and Dinan, T.G. (2010) Review: A Systematic Review of Hypothalamic-Pituitary-Adrenal Axis Function in Schizophrenia: Implications for Mortality. Journal of Psychopharmacology, 24, 91-118.
https://doi.org/10.1177/1359786810385491 |
| [20] | Manu, P., Correll, C.U., van Winkel, R., et al. (2012) Prediabetes in Patients Treated with Antipsychotic Drugs. Journal of Clinical Psychiatry, 73, 460-466. https://doi.org/10.4088/JCP.10m06822 |
| [21] | 马文华, 王兆琴, 赵衍山, 等. 长期服药对精神分裂症体重正常患者代谢性肥胖的影响[J]. 中国民康医学, 2017, 29(17): 4-7. |
| [22] | Jeon, S.W. and Kim, Y.K. (2017) Unresolved Is-sues for Utilization of Atypical Antipsychotics in Schizophrenia: Antipsychotic Polypharmacy and Metabolic Syndrome. International Journal of Molecular Sciences, 18, Article No. 2174.
https://doi.org/10.3390/ijms18102174 |
| [23] | Reynolds, G.P. and Kirk, S.L. (2010) Metabolic Side Effects of Anti-psychotic Drug Treatment—Pharmacological Mechanisms. Pharmacology & Therapeutics, 125, 169-179. https://doi.org/10.1016/j.pharmthera.2009.10.010 |
| [24] | 周燕, 苏珂, 胡永玲. 2型糖尿病患者血清瘦素水平与胰岛素抵抗的关系[J]. 陕西医学杂志, 2005, 34(7): 793-795. |
| [25] | Kieffer, T.J., Heller, R.S., Leech, C.A., Holz, G.G. and Habener, J.F. (1997) Leptin Suppression of Insulin Secretion by the Activation of Atp-Sensitive K+ Channels in Pancreatic Beta-Cells. Diabetes, 46, 1087-1093.
https://doi.org/10.2337/diabetes.46.6.1087 |
| [26] | 韩鹏飞, 陈长浩, 沈子童, 等. MECT联合第二代抗精神病药治疗精神分裂症的疗效及其对血清神经递质和免疫功能的影响[J]. 川北医学院学报, 2021, 36(6): 714-718. |
| [27] | 任春生, 林振东, 徐秀梅, 等. 无抽搐电休克与传统电休克治疗精神分裂症对照研究[J]. 中国健康心理学杂志, 2009, 17(10): 1167-1169. |
| [28] | Martinotti, G., Ricci, V., Di Nicola, M., et al. (2011) Brain-Derived Neurotrophic Factor and Electroconvulsive Therapy in a Schizophrenic Patient with Treatment-Resistant Paranoid-Hallucinatory Symptoms. The Journal of ECT, 27, e44-e46. https://doi.org/10.1097/YCT.0b013e318205e1c0 |
| [29] | 肖文焕, 李金, 张晓斌, 等. 精神分裂症患者改良电休克治疗前后血清胶质源性神经营养因子水平的变化[J]. 临床精神医学杂志, 2015, 25(2): 117-118. |
| [30] | Murray, N.M.F. (1991) Magnetic Stimulation of Cortex: Clinical Applications. Journal of Clinical Neurophysiology, 8, 66-76. https://doi.org/10.1097/00004691-199101000-00008 |
| [31] | 王晓明, 谢建平. 重复经颅磁刺激技术及其临床应用进展[J]. 国外医学(物理医学与康复学分册), 2004, 24(1): 43-46. |
| [32] | Butt, M.F., Al-busoda, A., Farmer, A.D. and Aziz, Q. (2020) The Anatomical Basis for Transcutaneous Auricular Vagus Nerve Stimu-lation. Journal of Anatomy, 236, 588-611. https://doi.org/10.1111/joa.13122 |
| [33] | Hasan, A., Wolff-Menzler, C., Pfeiffer, S., et al. (2015) Transcutaneous Noninvasive Vagus Nerve Stimulation (tVNS) in the Treatment of Schizophre-nia: A Bicentric Randomized Controlled Pilot Study. European Archives of Psychiatry and Clinical Neuroscience, 265, 589-600. https://doi.org/10.1007/s00406-015-0618-9 |
