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长链非编码RNA对心脏成纤维细胞功能的研究进展
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Abstract:
心脏成纤维细胞参与心脏各种损伤的修复，可以维持心脏结构和功能的完整。非编码RNA参与许多疾病的进展，已经成为进一步了解成纤维细胞的新方向，其中长链非编码RNAs (Long Non-Coding RNAs, LncRNAs)数量丰富、种类众多，本文总结通过调控心脏成纤维细胞参与心脏重构的长链非编码RNAs，并简述其作用机制。
Cardiac fibroblasts are involved in the repair of various cardiac injuries and can maintain the structural and functional integrity of the heart. The involvement of non-coding RNA in the pro-gression of many diseases has become a new direction for further understanding of fibroblasts, among which long non-coding RNAs (LncRNAs) are abundant and diverse. In this paper, we sum-marize the long non-coding RNAs involved in cardiac remodeling through regulation of cardiac fi-broblasts, and briefly describe their mechanisms of action.
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