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转录激活因子3在肿瘤中的研究进展
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Abstract:
转录激活因子3 (ATF3)属于ATF/环AMP反应元件结合(ATF/CREB)转录因子家族的成员，是一种应激诱导转录因子，在调节代谢、免疫和肿瘤发生中起着至关重要的作用。近几年，大量研究表明，ATF3在癌症的发生、发展、治疗和预后中发挥着关键作用，并且随着细胞类型和所处环境的不同，发挥着促癌或抑癌两种作用。本文详细阐述了ATF3在乳腺癌、前列腺癌、肝细胞癌、结直肠癌等多种恶性肿瘤中的调节作用，为其在肿瘤领域的深入研究及应用提供理论基础。
Activating transcription factor 3 (ATF3) is a member of the ATF/cyclic AMP response element binding (ATF/CREB) transcription factor family. It’s a stress-induced transcription factor that plays a vital role in regulating metabolism, immunity and tumorigenesis. In recent years, a large number of studies have shown that ATF3 plays a key role in the occurrence, development, treatment and prognosis of cancer. ATF3 can promote or inhibit cancer depending on cell type and environment. In this paper, the role of ATF3 in breast cancer, prostate cancer, hepatocellular carcinoma, colorectal cancer and other malignant tumors is reviewed, which will provide a theoretical basis for the deep-er research and application in the field of cancer.
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