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Vaginal Progesterone (VP) versus VP plus Intermittent Intramuscular Progesterone (IMP) Use in Frozen/Thawed Blastocyst Transfer Cycles: An Observational Cohort Study

DOI: 10.4236/ojog.2023.132021, PP. 192-206

Keywords: Vaginal Progesterone Supplementation, Progesterone Supplementation, IVF, Cryopreserved Embryo Transfer, Hormone Replacement Therapy

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Abstract:

Objective: Comparison of vaginal progesterone (VP) versus VP and intermittent intramuscular progesterone (IMP) use in frozen/thawed blastocyst transfer cycles. Study Design: A single center retrospective analyses of 470 elective FET cycles which were performed between January 2015 and September 2019 were evaluated. Patients were divided into two groups. Control group was consisted of VP (n = 272), the study group was consisted of VP plus IMP (n = 198) users. Results: The number of transfer attempts in control and study groups was 272 and 198, respectively. Age (29.8 ± 4 vs 30.6 ± 4; p = 0.09), BMI (22 ± 2 vs 21.9 ± 3; p = 0.79) and the number of transferred embryos (1.4 ± 0.5 vs 1.4 ± 0.5; p = 0.48) were comparable between groups. Altough, implantation rates (43.7% vs 43.6%; p = 0.9), ectopic pregnancy (0.8% vs 0.3%; p = 0.46) and abortion rates (8.2% vs 4.8%; p = 0.07) were similar. Biochemical pregnancy rate (8.4% vs 3.4% p = 0.01) in control group and ongoing pregnancy rate (OPR) (27.9% vs 38.1%; p = 0.005) in study group were significantly higher. Conclusion: Within the FET cycles in which good quality blastocyst are being transferred additional IMP supplementation to VP may increase OPR while reducing the biochemical pregnancy rate.

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