%0 Journal Article
%T Vaginal Progesterone (VP) versus VP plus Intermittent Intramuscular Progesterone (IMP) Use in Frozen/Thawed Blastocyst Transfer Cycles: An Observational Cohort Study
%A Serdar Celik
%A Dilek Cengiz Celik
%J Open Journal of Obstetrics and Gynecology
%P 192-206
%@ 2160-8806
%D 2023
%I Scientific Research Publishing
%R 10.4236/ojog.2023.132021
%X <strong>Objective:</strong> <span style=\"font-family:&quot;\"><span style=\"font-family:Verdana;\">Comparison of vaginal progesterone (VP) versus VP and intermittent
intramuscular progesterone (IMP) use in frozen/thawed blastocyst transfer
cycles. </span><b><span style=\"font-family:Verdana;\">Study Design: </span></b><span style=\"font-family:Verdana;\">A single center retrospective analyses of 470
elective FET cycles which were performed between January 2015 and September
2019 were evaluated. Patients were divided into two groups. Control group was
consisted of VP (n = 272), the study group was consisted of VP plus IMP (n = 198)
users. </span><b><span style=\"font-family:Verdana;\">Results: </span></b><span style=\"font-family:Verdana;\">The number of transfer attempts in control and study groups
w</span></span><span style=\"font-family:Verdana;\">as</span><span style=\"font-family:Verdana;\"> 272 and 198, respectively.
Age (29.8 ¡À 4 vs 30.6 ¡À 4; p = 0.09), BMI (22 ¡À 2 vs 21.9 ¡À 3; p = 0.79) and
the number of transferred embryos (1</span><span style=\"font-family:Verdana;\">.</span><span style=\"font-family:Verdana;\">4 ¡À 0</span><span style=\"font-family:Verdana;\">.</span><span style=\"font-family:Verdana;\">5 vs 1</span><span style=\"font-family:Verdana;\">.</span><span style=\"font-family:Verdana;\">4 ¡À 0</span><span style=\"font-family:Verdana;\">.</span><span style=\"font-family:Verdana;\">5; p = 0.48) were comparable
between groups. Altough, implantation rates (43.7% vs 43.6%; p = 0</span><span style=\"font-family:Verdana;\">.</span><span style=\"font-family:Verdana;\">9), ectopic pregnancy (0.8%
vs 0.3%; p = 0.46) and abortion rates (8</span><span style=\"font-family:Verdana;\">.</span><span style=\"font-family:Verdana;\">2% vs 4.8%; p = 0.07) were similar. Biochemical
pregnancy rate (8</span><span style=\"font-family:Verdana;\">.</span><span style=\"font-family:&quot;\"><span style=\"font-family:Verdana;\">4% vs 3.4%
p = 0.01) in control group and ongoing pregnancy rate (OPR) (27.9% vs 38.1%; p
= 0.005) in study group were significantly higher. </span><b><span style=\"font-family:Verdana;\">Conclusion:</span></b><span style=\"font-family:Verdana;\"> Within
the FET cycles in which good quality blastocyst are being transferred
additional IMP supplementation to VP may increase OPR while reducing the
biochemical pregnancy rate.</span></span>
%K Vaginal Progesterone Supplementation
%K Progesterone Supplementation
%K IVF
%K Cryopreserved Embryo Transfer
%K Hormone Replacement Therapy
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=123080