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钠钙交换体与心肌缺血/再灌注性心律失常
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Abstract:
钠–钙交换体(Na+/Ca2+ exchanger, NCX)是维持心肌细胞钙稳态的重要结构，与心肌正常电活动和收缩、舒张密切相关。在心肌缺血/再灌注性心律失常的发生过程中，NCX活动增强并参与了心肌细胞钙超载的诱发。近年来随着人们对NCX研究的不断深入以及新型工具药的研发和应用，抑制心肌钠–钙交换活动有望成为今后干预心肌缺血/再灌注性心律失常的新方向和新途径。
Na+/Ca2+ exchanger (NCX) is an important structure to maintain calcium homeostasis in cardiomyocytes, which is closely related to normal electrical activity, contraction and relaxation of myocardium. During the occurrence of myocardial ischemia/reperfusion arrhythmias, NCX activity is enhanced and participates in the induction of calcium overload in cardiomyocytes. In recent years, with the continuous deepening of NCX research and the development and application of new tool drugs, inhibiting myocardial sodium calcium exchange activity is expected to become a new direction and new way to intervene myocardial ischemia/reperfusion arrhythmia in the future.
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