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妊娠期糖尿病母亲对新生儿维生素A、D、E水平的影响
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Abstract:
目的:研究妊娠期糖尿病(GDM)母亲对新生儿维生素A、D、E水平的影响。方法:选取2021年6月至2022年6月于本院产科收治的GDM孕妇及其新生儿100例作为观察组,另外选取同期在本院产科分娩的非GDM孕妇及其足月新生儿100例作为对照组。采用高效液相色谱法比较两组新生儿维生素A、D、E水平,分析GDM母亲对新生儿维生素A、D、E水平的影响。结果:两组新生儿维生素水平有明显差异。与对照组相比,观察组新生儿维生素A、维生素E水平较高,而维生素D水平较低。结论:GDM母亲所生新生儿维生素A、维生素E水平明显上升,维生素D水平较低,应针对GDM母亲及正常孕妇科学足量补充维生素A、D、E,有效减少新生儿疾病的发生。
Objective: To study the effect of mothers with gestational diabetes mellitus (GDM) on neonatal lev-els of vitamin A, D and E. Methods: 100 GDM pregnant women and their newborns admitted to the hospital from June 2021 to June 2022 were selected as the observation group, and 100 non-GDM pregnant women and their term newborns delivered in the same period were selected as the con-trol group. The levels of vitamin A, D, and E analyzed the effects of GDM mothers on neonatal vita-min A, D, and E levels. Results: Vitamin levels were significantly between the two groups. In the ob-served group, vitamin A and vitamin D levels were lower compared with the control group. Conclu-sion: The level of vitamin A and vitamin E born in GDM mothers has increased significantly, and the low vitamin D levels should be scientifically and fully supplemented for GDM mothers and normal pregnant women to effectively reduce the occurrence of neonatal diseases.
[1] | Shahbazian, H., Nouhjah, S., Shahbazian, N., et al. (2016) Gestational Diabetes Mellitus in an Iranian Pregnant Popula-tion Using IADPSG Criteria: Incidence, Contributing Factors and Outcomes. Diabetology & Metabolic Syndrome, 10, 242-246. https://doi.org/10.1016/j.dsx.2016.06.019 |
[2] | 陈竞, 胡贻椿, 杨春, 等. 2010-2012年中国城市老年人维生素A营养状况[J]. 中国预防医学杂志, 2017, 51(2): 121-124. |
[3] | 程晨, 包蕾. 维生素A与早产儿呼吸窘迫综合征相关性分析[J]. 儿科药学杂志, 2014, 20(10): 53-56. |
[4] | 中华医学会妇产科学分会产科学组. 孕前和孕期保健指南[J]. 中华妇产科杂志, 2018, 53(1): 7-13. |
[5] | 顾志勇, 余加林. 维生素A与新生儿肺炎、败血症及呼吸窘迫综合征相关性的临床研究[J]. 儿科药学杂志, 2015, 21(6): 4-6. |
[6] | 刘登礼, 何必子. 不同胎龄和不同出生体重新生儿出生时血清维生素A水平测定[J]. 中国新生儿科杂志, 2015, 30(5): 358-360. |
[7] | Handel, M.N., Frederiksen, P., Cohen, A., et al. (2017) Neonatal Vitamin D Status from Archived Dried Blood Spots and Future Risk of Fractures in Childhood: Results from the D-Tect Study, a Population-Based Case-Cohort Study. The American Jour-nal of Clinical Nutrition, 106, 155-161. https://doi.org/10.3945/ajcn.116.145599 |
[8] | Uday, S., Fratzl-Zelman, N., Roschger, P., et al. (2018) Cardiac, Bone and Growth Plate Manifestation in Hypocalcemic Infants: Revealing the Hidden Body of the Vitamin D Deficiency Iceberg. BMC Pediatrics, 18, Article No. 183.
https://doi.org/10.1186/s12887-018-1159-y |
[9] | 陈远华. 母体孕期维生素D状况与胎儿宫内生长受限的关联研究[D]: [博士学位论文]. 合肥: 安徽医科大学, 2014. |
[10] | 尹俊芳, 陈煜. 血清维生素A及维生素E水平测定在胎膜早破孕产妇中的意义探析[J]. 临床医药文献电子杂志, 2019, 6(41): 136-137. |
[11] | Santra, D., Sawhney, H., Aggarwal, N., et al. (2003) Lipid Peroxidation and Vitamin Estatus in Gestational Diabetes Mellitus. Journal of Obstet-rics and Gynaecology Research, 29, 300-304.
https://doi.org/10.1046/j.1341-8076.2003.00127.x |
[12] | Suhail, M., Patil, S., Khan, S., et al. (2010) Antioxidant Vitamins and Lipoperoxidation in Non-Pregnant, Pregnant, and Gestational Diabetic Women: Erythrocytes Osmotic Fra-gility Profiles. Journal of Clinical Medicine Research, 2, 266-273. https://doi.org/10.4021/jocmr454w |
[13] | Hekmat, K., Bagheri, R., Abedi, P., et al. (2014) The Relationship of Fat Soluble Antioxidants with Gestational Diabetes in Iran: A Case-Control Study. The Journal of Maternal-Fetal & Neonatal Medicine, 27, 1676-1679.
https://doi.org/10.3109/14767058.2014.892921 |
[14] | 谢幸, 孔北华, 段涛. 妇产科学[M]. 第九版. 北京: 人民卫生出版社, 2018: 105-109. |
[15] | 中华医学会妇产科学分会产科学组, 中华医学会围产医学分会妊娠合并糖尿病协作组. 妊娠合并糖尿病诊治指南(2014) [J]. 中华妇产科杂志, 2014, 49(8): 561-569. |
[16] | 孙学文, 刘莹莹, 谢军, 等. 超高效液相色谱-串联质谱法同时测定特殊医学用途配方食品中5种脂溶性维生素[J]. 中国食品药品监管, 2020(6): 64-69. |
[17] | 陈宝伶. 儿童过敏性紫癜与维生素A、D、E水平的相关性研究[J]. 中国现代医生, 2017, 55(31): 17-20. |
[18] | 申南, 陆娣, 郑春梅, 等. 常规保健下不同年龄段孕妇妊娠早期血清维生素A、E水平分析[J]. 中国妇产科临床杂志, 2018, 19(4): 356-358. |
[19] | 陈慝敏, 吴锦晖, 孙静, 等. 妊娠期糖尿病孕妇的微量营养素特征分析[J]. 中国药业, 2016, 25(11): 82-85. |
[20] | 宋丹, 路旭宏, 胡向红, 等. 脂溶性维生素A、D、E与妊娠期糖尿病的相关性分析[J]. 现代生物医学进展, 2020, 1(25): 115-118. |
[21] | Morris, S.K., Pell, L.G., Rahman, M.Z., et al. (2016) Maternal Vitamin D Supplement during Pregnancy and Lactation to Prevent Acute Respiratory Infections in Infancy in Dhaka, Bangladesh (MDARI Trial): Protocol for a Prospective Cohort Study Nested within a Randomize Dcontrolledtria. BMC Pregnancy Child Birth, 16, Article No. 309.
https://doi.org/10.1186/s12884-016-1103-9 |
[22] | Grant, W.B. (2011) Adequate Vitamin D during Pregnancy Re-duces the Risk of Premature Birth by Reducing Placental Colonization by Bacterial Vaginosis Species. Mbio, 2, e00022-11. https://doi.org/10.1128/mBio.00022-11 |
[23] | Willms, A., MuHer, C., Julich, H., et al. (2016) Tu-mour-Associated Circulating Microparticles: A Novel Liquid Biopsy Tool for Screening and Therapy Monitoring of Colorectal Carcinoma and Other Epithelial Neoplasia. Oncotarget, 7, 867-875. https://doi.org/10.18632/oncotarget.9018 |