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高原地区胎膜早破脐带血IL-6、CRP水平在早发性新生儿败血症中的研究进展
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Abstract:
胎膜早破与生殖道感染两者相辅相成，同早发性新生儿败血症关系密切，由于新生儿免疫系统发育不成熟，且缺乏特异性的临床表现，常致严重不良预后。IL-6、CRP两炎性因子可在胎膜早破合并感染及早发性新生儿败血症发生时异常升高。脐带血是胎儿出生时第一时间获得的血液样本，对于早发性新生儿败血症的早期诊断价值较高。本文就胎膜早破患者脐带血IL-6、CRP水平与早发性新生儿败血症相关性进行综述，以期对早发性新生儿败血症做到早发现、早诊断、早治疗，改善新生儿预后。
Premature rupture of membranes and genital tract infection complement each other and are close-ly related to early-onset neonatal sepsis. Due to the immaturity of the neonatal immune system and the lack of specific clinical manifestations, it often leads to a severe and poor prognosis. The two in-flammatory factors IL-6 and CRP can be abnormally elevated in premature rupture of membranes complicated by infection and early-onset neonatal sepsis. Umbilical cord blood is the first blood sample obtained when the fetus is born, and has a high value for the early diagnosis of early-onset neonatal sepsis. This article reviews the correlation between umbilical cord blood IL-6 and CRP lev-els in patients with premature rupture of membranes and early-onset neonatal sepsis, in order to achieve early detection, early diagnosis and early treatment of early-onset neonatal sepsis, and im-prove the prognosis of neonates.
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