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肠道菌群–大麻素系统与早泄的研究进展
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Abstract:
早泄是常见的性功能障碍疾病之一，选择性5-羟色胺再摄取抑制剂因提高5-羟色胺(5-hydroxytryptamine, 5-HT)浓度在治疗抑郁症时能有效延长射精潜伏时间。目前的研究指出大麻素系统与5-HT系统在功能上相互影响且相互依赖。肠道菌群能够调节机体代谢组成并以5-HT为介导最终影响个体情绪与应激，通过益生菌治疗能有效逆转肠道菌群的情绪反应。本文基于肠道菌群及大麻素系统，深入探讨肠道菌群与早泄疾病发生及治疗上的相关性。
Premature ejaculation is one of the common sexual dysfunction diseases. Selective serotonin reuptake inhibitors can effectively prolong ejaculation latency in the treatment of depression by increasing the concentration of 5-HT. Current research points to the functional interaction and in-terdependence of the cannabinoid system and the 5-HT system. Intestinal flora can regulate the body’s metabolic composition and ultimately affect individual mood and stress through 5-HT. Pro-biotic treatment can effectively reverse the emotional response of gut flora. Based on the gut micro-biota and cannabinoid system, this paper deeply explores the correlation between the gut microbi-ota and the occurrence and treatment of premature ejaculation.
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