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非编码RNA与缺血性卒中出血转化后血脑屏障关系研究进展
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Abstract:
出血性转化是急性缺血性卒中后的一种常见并发症，导致不良的预后。目前认为，出血转化的发生与血脑屏障的破坏密切相关。近年来发现非编码RNA可以作为基因表达的转录后调节因子在血脑屏障通透性中起着至关重要的作用。本文就血脑屏障与出血转化、非编码RNA之间内在联系方面的研究进展进行综述，以探索非编码RNA在缺血性卒中后出血转化血脑屏障中的作用。
Hemorrhagic transformation is a common complication after acute ischemic stroke, which leads to poor prognosis. At present, it is believed that the occurrence of hemorrhagic transformation is closely related to the destruction of the blood-brain barrier. In recent years, it has been found that non-coding RNA can be used as a post-transcriptional regulator of gene expression and plays an important role in blood-brain barrier permeability. This article reviews the research progress on the internal relationship between blood-brain barrier, hemorrhagic transformation and non-coding RNA, in order to explore the role of non-coding RNA in the transformation of blood-brain barrier af-ter ischemic stroke.
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