|
|
慢性低氧暴露脑认知、结构和功能MRI研究进展
|
Abstract:
高原有着特殊的自然环境，其特点是低压、低氧、气候干燥寒冷、太阳辐射和紫外线照射强等，其中低压低氧是影响人体生理功能最显著的因素。大脑作为高耗氧器官，对低氧反应尤为敏感，低氧环境必然会对大脑造成不同程度的损害。既往研究表明，急性低氧环境暴露能造成学习、记忆等认知功能损害，但目前针对慢性低氧环境暴露诱导认知损害的相关研究较少。磁共振成像(Magnetic Resonance Imaging, MRI)因具有无创、无辐射、空间分辨率高、覆盖范围广及可重复性强等优势，已成为研究神经认知功能领域的主要手段。因此，深入研究慢性低氧人群的MRI对寻找神经认知功能损伤的影像学生物标记、早期预测、风险评估和治疗效果均具有重要意义。
The plateau has special natural environment, which is characterized by low pressure, low oxygen, dry and cold climate, strong solar radiation and ultraviolet radiation, among which low pressure and low oxygen are the most significant factors affecting human physiological functions. As an organ with high oxygen consumption, the brain is particularly sensitive to hypoxia, and hypoxia environ-ment will inevitably cause damage to the brain to varying degrees. Previous studies have shown that acute hypoxic environmental exposure can cause cognitive impairment such as learning and memory, but there are few relevant studies on the cognitive impairment induced by chronic hypox-ic environmental exposure. Magnetic Resonance Imaging (MRI) has become the main means to study neurocognitive function due to its advantages of non-invasive, non-radiation, high spatial res-olution, wide coverage and strong repeatability. Therefore, an in-depth study of MRI in chronic hy-poxia population is of great significance for finding imaging biomarkers of neurocognitive impair-ment, early prediction, risk assessment and therapeutic effect.
| [1] | Zhang, J., Yan, X., Shi, J., Gong, Q., Weng, X. and Liu, Y. (2010) Structural Modifications of the Brain in Acclimatiza-tion to High-Altitude. PLOS ONE, 5, e11449. https://doi.org/10.1371/journal.pone.0011449 |
| [2] | Ma, H., Wang, Y., Wu, J., Wang, B., Guo, S., Luo, P., et al. (2015) Long-Term Exposure to High Altitude Affects Conflict Control in the Conflict-Resolving Stage. PLOS ONE, 10, e0145246.
https://doi.org/10.1371/journal.pone.0145246 |
| [3] | Hogan, A.M., Virues-Ortega, J., Botti, A.B., Bucks, R., Hol-loway, J.W., Rose-Zerilli, M.J., et al. (2010) Development of Aptitude at Altitude. Developmental Science, 13, 533-544. https://doi.org/10.1111/j.1467-7687.2009.00909.x |
| [4] | Yan, X., Zhang, J., Gong, Q. and Weng, X. (2011) Adap-tive Influence of Long Term High Altitude Residence on Spatial Working Memory: An fMRI Study. Brain and Cogni-tion, 77, 53-59. https://doi.org/10.1016/j.bandc.2011.06.002 |
| [5] | Yan, X., Zhang, J., Gong, Q. and Weng, X. (2011) Prolonged High-Altitude Residence Impacts Verbal Working Memory: An fMRI Study. Experimental Brain Re-search, 208, 437-445. https://doi.org/10.1007/s00221-010-2494-x |
| [6] | Chen, X., Zhang, Q., Wang, J., Liu, J., Zhang, W., Qi, S., et al. (2017) Cognitive and Neuroimaging Changes in Healthy Immigrants upon Relocation to a High Altitude: A Panel Study. Human Brain Mapping, 38, 3865-6877.
https://doi.org/10.1002/hbm.23635 |
| [7] | Yuan, H., Wang, Y., Liu, P.F., Yue, Y.L., Guo, J.S. and Wang, Z.C. (2019) Abnormal Brain Activity in Rats with Sustained Hypobaric Hypoxia Exposure: A Resting-State Functional Mag-netic Resonance Imaging Study. Chinese Medical Journal, 132, 2621-2627. https://doi.org/10.1097/CM9.0000000000000495 |
| [8] | Olaithe, M., Bucks, R.S., Hillman, D.R. and Eastwood, P.R. (2018) Cognitive Deficits in Obstructive Sleep Apnea: Insights from a Meta-Review and Comparison with Deficits Ob-served in COPD, Insomnia, and Sleep Deprivation. Sleep Medicine Reviews, 38, 39-49. https://doi.org/10.1016/j.smrv.2017.03.005 |
| [9] | Zhang, J., Liu, H., Yan, X. and Weng, X. (2011) Minimal Effects on Human Memory Following Long-Term Living at Moderate Altitude. High Altitude Medicine & Biology, 12, 37-43. https://doi.org/10.1089/ham.2009.1085 |
| [10] | Nemoto, K. (2017) Understanding Voxel-Based Morphometry. Brain and Nerve [Shinkei kenkyu no shinpo], 69, 505-511. |
| [11] | Bao, H., He, X., Wang, F. and Kang, D. (2021) Study of Brain Structure and Function in Chronic Mountain Sickness Based on fMRI. Frontiers in Neurology, 12, Article ID: 763835. https://doi.org/10.3389/fneur.2021.763835 |
| [12] | 刘彩霞, 鲍海华, 李伟霞, 赵希鹏, 吴有森, 张红迁, 等. 慢性高原病患者脑灰质变化的VBM-MRI研究[J]. 磁共振成像, 2014, 5(3): 211-215. |
| [13] | Yan, X., Zhang, J., Shi, J., Gong, Q. and Weng, X. (2010) Cerebral and Functional Adaptation with Chronic Hypoxia Exposure: A Multi-Modal MRI Study. Brain Research, 1348, 21-29. https://doi.org/10.1016/j.brainres.2010.06.024 |
| [14] | Zhang, J., Zhang, H., Li, J., Chen, J., Han, Q., Lin, J., et al. (2013) Adaptive Modulation of Adult Brain Gray and White Matter to High Alti-tude: Structural MRI Studies. PLOS ONE, 8, e68621.
https://doi.org/10.1371/journal.pone.0068621 |
| [15] | Zatorre, R.J., Fields, R.D. and Johansen-Berg, H. (2012) Plas-ticity in Gray and White: Neuroimaging Changes in Brain Structure during Learning. Nature Neuroscience, 15, 528-536. https://doi.org/10.1038/nn.3045 |
| [16] | Varentsova, A., Zhang, S. and Arfanakis, K. (2014) Development of a High Angular Resolution Diffusion Imaging Human Brain Template. NeuroImage, 91, 177-186. https://doi.org/10.1016/j.neuroimage.2014.01.009 |
| [17] | Basser, P.J., Mattiello, J. and Lebihan, D. (1994) MR Dif-fusion Tensor Spectroscopy and Imaging. Biophysical Journal, 66, 259-267. https://doi.org/10.1016/S0006-3495(94)80775-1 |
| [18] | Chen, X., Li, H., Zhang, Q., Wang, J., Zhang, W., Liu, J., et al. (2019) Combined Fractional Anisotropy and Subcortical Volumetric Abnormalities in Healthy Immigrants to High Altitude: A Longitudinal Study. Human Brain Mapping, 40, 4202-4212. https://doi.org/10.1002/hbm.24696 |
| [19] | Chen, J., Fan, C., Li, J., Han, Q., Lin, J., Yang, T., et al. (2016) Increased Intraregional Synchronized Neural Activity in Adult Brain after Prolonged Adaptation to High-Altitude Hypoxia: A Resting-State fMRI Study. High Altitude Medicine & Biology, 17, 16-24. https://doi.org/10.1089/ham.2015.0104 |
| [20] | Chen, X., Liu, J., Wang, J., Xin, Z., Zhang, Q., Zhang, W., et al. (2021) Altered Resting-State Networks May Explain the Executive Impairment in Young Health Immigrants into High-Altitude Area. Brain Imaging and Behavior, 15, 147-156. https://doi.org/10.1007/s11682-019-00241-1 |
