%0 Journal Article
%T 慢性低氧暴露脑认知、结构和功能MRI研究进展<br>Advances in Cognitive, Structural and Functional MRI of Brain Exposed to Chronic Hypoxia
%A 曹顺道
%A 吉维忠
%J Advances in Clinical Medicine
%P 5621-5626
%@ 2161-8720
%D 2022
%I Hans Publishing
%R 10.12677/ACM.2022.126813
%X 高原有着特殊的自然环境，其特点是低压、低氧、气候干燥寒冷、太阳辐射和紫外线照射强等，其中低压低氧是影响人体生理功能最显著的因素。大脑作为高耗氧器官，对低氧反应尤为敏感，低氧环境必然会对大脑造成不同程度的损害。既往研究表明，急性低氧环境暴露能造成学习、记忆等认知功能损害，但目前针对慢性低氧环境暴露诱导认知损害的相关研究较少。磁共振成像(Magnetic Resonance Imaging, MRI)因具有无创、无辐射、空间分辨率高、覆盖范围广及可重复性强等优势，已成为研究神经认知功能领域的主要手段。因此，深入研究慢性低氧人群的MRI对寻找神经认知功能损伤的影像学生物标记、早期预测、风险评估和治疗效果均具有重要意义。<br />
The plateau has special natural environment, which is characterized by low pressure, low oxygen, dry and cold climate, strong solar radiation and ultraviolet radiation, among which low pressure and low oxygen are the most significant factors affecting human physiological functions. As an organ with high oxygen consumption, the brain is particularly sensitive to hypoxia, and hypoxia environ-ment will inevitably cause damage to the brain to varying degrees. Previous studies have shown that acute hypoxic environmental exposure can cause cognitive impairment such as learning and memory, but there are few relevant studies on the cognitive impairment induced by chronic hypox-ic environmental exposure. Magnetic Resonance Imaging (MRI) has become the main means to study neurocognitive function due to its advantages of non-invasive, non-radiation, high spatial res-olution, wide coverage and strong repeatability. Therefore, an in-depth study of MRI in chronic hy-poxia population is of great significance for finding imaging biomarkers of neurocognitive impair-ment, early prediction, risk assessment and therapeutic effect.
%K 慢性低氧，磁共振成像，脑结构，脑功能<br>Chronic Hypoxia
%K Magnetic Resonance Imaging
%K Brain Structure
%K Brain Function
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=52718