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一锅串联法合成β-酮砜化合物及其衍生物
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Abstract:
本文介绍了通过一锅串联法实现了从α-一溴甲基酮合成β-酮砜及其衍生类化合物的过程。在溶剂为乙醇和水(3:1/v:v)中，α-一溴甲基酮与对甲苯亚磺酸钠发生取代反应合成了β-酮砜化合物，后又分别加入硼氢化钠、盐酸羟胺、苯肼生成了β-酮砜类衍生化物，该方法溶剂绿色环保，后处理简单，产率损失较少，底物适应范围性广，所得已知化合物结构经1H NMR分析确证。
This paper describes the synthesis of β-ketosulfones and their derivatives from α-bromomethyl ketones by a one-pot tandem method. In the solvent of ethanol and water (3:1/v:v), α-Monobro-momethyl ketone and sodium p-toluenesulfinate were substituted to synthesize β-ketosulfone compounds, and then sodium borohydride, hydroxylamine hydrochloride, and phenylhydrazine were added to form β-ketosulfone derivatives. The method has the advantages of green solvent, simple post-processing, less yield loss, wide substrate adaptability. The known compound structure was confirmed by 1H NMR analysis.
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