%0 Journal Article
%T 一锅串联法合成β-酮砜化合物及其衍生物<br>One-Pot Tandem Method Synthesis of β-Ketosulfone Compounds and Their Derivatives
%A 张蕾
%A 古丽扎拜尔·阿不力皮孜
%A 阿布都热西提·阿布力克木
%J Hans Journal of Chemical Engineering and Technology
%P 226-233
%@ 2161-8852
%D 2022
%I Hans Publishing
%R 10.12677/HJCET.2022.123030
%X 本文介绍了通过一锅串联法实现了从α-一溴甲基酮合成β-酮砜及其衍生类化合物的过程。在溶剂为乙醇和水(3:1/v:v)中，α-一溴甲基酮与对甲苯亚磺酸钠发生取代反应合成了β-酮砜化合物，后又分别加入硼氢化钠、盐酸羟胺、苯肼生成了β-酮砜类衍生化物，该方法溶剂绿色环保，后处理简单，产率损失较少，底物适应范围性广，所得已知化合物结构经<sup>1</sup>H NMR分析确证。<br />
This paper describes the synthesis of β-ketosulfones and their derivatives from α-bromomethyl ketones by a one-pot tandem method. In the solvent of ethanol and water (3:1/v:v), α-Monobro-momethyl ketone and sodium p-toluenesulfinate were substituted to synthesize β-ketosulfone compounds, and then sodium borohydride, hydroxylamine hydrochloride, and phenylhydrazine were added to form β-ketosulfone derivatives. The method has the advantages of green solvent, simple post-processing, less yield loss, wide substrate adaptability. The known compound structure was confirmed by <sup>1</sup>H NMR analysis.
%K 一锅串联法，α-一溴甲基酮，β-酮砜化合物，β-酮砜衍生化物<br>One-Pot Tandem Method
%K α-Bromomethyl Ketone
%K β-Ketosulfone Compounds
%K β-ketosulfone Derivatives
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=52005