Objective: Celiac disease (CD) is an immune-mediated systemic disorder triggered by
gluten. It has a variable combination of clinical manifestations and changes that have been occurring in
recent decades however they are not known in detail. The purpose of the article
is to compare Classical and Non-Classical CD cases in terms of demographic
characteristics, duodenal biopsy, extraintestinal manifestations, and
associated comorbidities. Materials and Methods: A comparative
retrospective cohort study from January 2008 to December 2018. Results: A
total of 128 cases were included: 84 Classical (66%) and 44 Non-Classical CD
(34%). The family history of CD was identified in 14% of cases without
differences between groups. The age at diagnosis was distinct for Classical and
Non-Classical CD (4.9 ± 4 and 8.3 ± 4 years old; p<0.001),
respectively. Important changes were found within the classical presentation,
including monosymptoms
and a significantly higher rate of intestinal atrophy; p=0.04. The
main Non-Classical CD symptom was recurrent abdominal pain. The extraintestinal
manifestations (EIM) were identified in 42% and occurred in both groups. The comparison between
groups showed differences in rates of migraine and vitamin D deficiency and was higher for Non-Classical CD
(p<0.05). Associated diseases
occurred in
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