%0 Journal Article
%T Classical and Non-Classical Celiac Disease Comparison: Ten Years of Study
%A Katia Regina Pena Schesquini-Roriz
%A Jocelyn Cristina Betancourt Castellanos
%A Laura Martinez Martinez
%A Gloria Maria Fraga Rodriguez
%A Susana Boronat Guerrero
%A Isabel Badell Serra
%J Open Journal of Pediatrics
%P 309-319
%@ 2160-8776
%D 2022
%I Scientific Research Publishing
%R 10.4236/ojped.2022.122034
%X <strong>Objective:</strong><span style=\"font-family:Verdana;\"> Celiac disease (CD) is an immune-mediated systemic disorder triggered by
gluten. It has a variable combination of clinical manifestations and changes </span><span style=\"font-family:Verdana;\">that </span><span style=\"font-family:&quot;\"><span style=\"font-family:Verdana;\">have been occurring in
recent decades however they are not known in detail. The purpose of the article
is to compare Classical and Non-Classical CD cases in terms of demographic
characteristics, duodenal biopsy, extraintestinal manifestations, and
associated comorbidities. </span><b><span style=\"font-family:Verdana;\">Materials and Methods: </span></b><span style=\"font-family:Verdana;\">A comparative
retrospective cohort study from January 2008 to December 2018. </span><b><span style=\"font-family:Verdana;\">Results: </span></b><span style=\"font-family:Verdana;\">A
total of 128 cases were included: 84 Classical (66%) and 44 Non-Classical CD
(34%). The family history of CD was identified in 14% of cases without
differences between groups. The age at diagnosis was distinct for Classical and
Non-Classical CD (4.9 ¡À 4 and 8.3 ¡À 4 years old; p</span></span><span style=\"font-family:&quot;\"> </span><span style=\"font-family:Verdana;\">&lt;</span><span style=\"font-family:&quot;\"> </span><span style=\"font-family:Verdana;\">0.001),
respectively. Important changes were found within the classical presentation,
including mono</span><span style=\"font-family:&quot;\"> </span><span style=\"font-family:Verdana;\">symptoms
and a significant</span><span style=\"font-family:Verdana;\">ly</span><span style=\"font-family:Verdana;\"> higher rate of intestinal atrophy; p</span><span style=\"font-family:&quot;\"> </span><span style=\"font-family:Verdana;\">=</span><span style=\"font-family:&quot;\"> </span><span style=\"font-family:Verdana;\">0.04. The
main Non-Classical CD symptom was recurrent abdominal pain. The extraintestinal
manifestations (EIM) w</span><span style=\"font-family:Verdana;\">ere</span><span style=\"font-family:Verdana;\"> identified in 42% and occurred in both groups. The comparison between
groups showed differences in rates of migraine and vitamin D deficiency and w</span><span style=\"font-family:Verdana;\">as</span><span style=\"font-family:Verdana;\"> higher for Non-Classical CD
(p</span><span style=\"font-family:&quot;\"> </span><span style=\"font-family:Verdana;\">&lt;</span><span style=\"font-family:&quot;\"> </span><span style=\"font-family:Verdana;\">0.05). Associated diseases
occurred in
%K Celiac Disease
%K Gluten Allergy
%K Extra-Intestinal Manifestation
%K Disease Associated with Celiac Disease
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=116831