Expression of miR-155 and miR-146a in Skin Tissue, Peripheral Blood Mononuclear Cells and Serum of Patients with Psoriasis and Its Clinical Significance
Objective: To explore the expression and clinical significance of miR-155 and miR-146a
in psoriasis patients from different sources. Methods: The expression
levels of miR-155 and miR-146a in psoriasis vulgaris tissues, peripheral blood
mononuclear cells, and
serum were detected by the QRT-PCR method in 30 patients with psoriasis vulgaris and 30 healthy
subjects as the normal control group, and the correlation between the
expression levels of miR-155 and miR-146a in psoriasis samples from different
sources was analyzed. And the expression levels of miR-155 and miR-146a in
peripheral blood mononuclear cells, and serum after treatment. Results: The expression of miR-155 and
miR-146a in skin tissue, peripheral blood mononuclear cells and serum of
patients with psoriasis was significantly higher than that of normal controls
(P < 0.01). miR-155 and miR-146a were highly expressed in skin tissue,
peripheral blood mononuclear cells and serum of the psoriasis experimental group (P < 0.01). After
treatment, the expression of miR-155 and miR-146a in peripheral blood
mononuclear cells and serum decreased (P < 0.05). Conclusions: The
significantly increased levels of miR-155 and miR-146a in psoriasis samples
from different sources may mediate the immune mechanism involved in the activity
process of psoriasis.
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