%0 Journal Article
%T Expression of miR-155 and miR-146a in Skin Tissue, Peripheral Blood Mononuclear Cells and Serum of Patients with Psoriasis and Its Clinical Significance
%A Dongcheng Gu
%A Maojie Cheng
%A Jurui Feng
%J Advances in Bioscience and Biotechnology
%P 207-215
%@ 2156-8502
%D 2022
%I Scientific Research Publishing
%R 10.4236/abb.2022.134011
%X <b><span style=\"font-family:&quot;\">Objective:</span></b><span style=\"font-family:&quot;\"> To explore the expression and clinical significance of miR-155 and miR-146a
in psoriasis patients from different sources. <b>Methods:</b> The expression
levels of miR-155 and miR-146a in psoriasis vulgaris tissues, peripheral blood
mononuclear cells</span><span style=\"font-family:&quot;\">,</span><span style=\"font-family:&quot;\"> and
serum were detected by </span><span style=\"font-family:&quot;\">the </span><span style=\"font-family:&quot;\">QRT-PCR method in 30 patients with psoriasis vulgaris and 30 healthy
subjects as the normal control group, and the correlation between the
expression levels of miR-155 and miR-146a in psoriasis samples from different
sources was analyzed. And the expression levels of miR-155 and miR-146a in
peripheral blood mononuclear cells</span><span style=\"font-family:&quot;\">,</span><span style=\"font-family:&quot;\"> and serum after treatment. <b>Results:</b> The expression of miR-155 and
miR-146a in skin tissue, peripheral blood mononuclear cells and serum of
patients with psoriasis was significantly higher than that of normal controls
(P &lt; 0.01). miR-155 and miR-146a were highly expressed in skin tissue,
peripheral blood mononuclear cells and serum of </span><span style=\"font-family:&quot;\">the </span><span style=\"font-family:&quot;\">psoriasis experimental group (P &lt; 0.01). After
treatment, the expression of miR-155 and miR-146a in peripheral blood
mononuclear cells and serum decreased (P &lt; 0.05). <b>Conclusions:</b> The
significantly increased levels of miR-155 and miR-146a in psoriasis samples
from different sources may mediate the immune mechanism involved in the activity
process of psoriasis.
%K Psoriasis
%K miR-155
%K miR-146a
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=116873