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Synthesis and Evaluation of Quinolino-Benzoxaboroles as Potential Antimicrobial Agents

DOI: 10.4236/ijoc.2022.122005, PP. 53-63

Keywords: Benzoxaboroles, Aminobenzoxaboroles, Quinolino-Benzoxaboroles, Anti-Microbial Agents

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Abstract:

Several quinolino-benzoxaborole derivatives have been prepared to start from aminobenzoxaboroles. These derivatives have been evaluated for their anti-cancer activity on human and murine cancer cell lines and based on their relative non-toxicity, these compounds were further evaluated for their antibacterial activity against E. coli, B. subtilis, and M. smegmatis. The synthesized compounds were also evaluated for antifungal activity in C. albicans and C. neoformans.

References

[1]  Shang, X.F., Morris-Natschke, S.L., Liu, Y.Q., Guo, X., Xu, X.S., Goto, M., Li, J.C., Yang, G.Z. and Lee, K.H. (2018) Biologically Active Quinoline and Quinazoline Alkaloids Part I. Medicinal Research Reviews, 38, 775-828.
https://doi.org/10.1002/med.21466
[2]  El-Gamal, K.M.A., Sherbiny, F.F., El-Morsi, A.M., Abu-El-khair, H.E., Eissa, I.H. and El-Sebaei, M.M. (2015) Design, Synthesis and Antimicrobial Evaluation of Some Novel Quinoline Derivatives. Pharmacy & Pharmacology International Journal, 2, 165-177.
https://doi.org/10.15406/ppij.2015.02.00036
[3]  Vandekerckhove, S. and D’hooghe, M. (2015) Quinoline-Based Antimalarial Hybrid Compounds. Bioorganic & Medicinal Chemistry, 23, 5098-5119.
https://doi.org/10.1016/j.bmc.2014.12.018
[4]  Jain, S., Chandra, V., Kumar Jain, P., Pathak, K., Pathak, D. and Vaidya, A. (2019) Comprehensive Review on Current Developments of Quinoline-Based Anticancer Agents. Arabian Journal of Chemistry, 12, 4920-4946.
https://doi.org/10.1016/j.arabjc.2016.10.009
[5]  Weyesa, A. and Mulugeta, E. (2020) Recent Advances in the Synthesis of Biologically and Pharmaceutically Active Quinoline and Its Analogues: A Review. RSC Advances, 10, 20784-20793.
https://doi.org/10.1039/D0RA03763J
[6]  Browning, D.J. (2014) Pharmacology of Chloroquine and Hydroxychloroquine. In: Hydroxychloroquine and Chloroquine Retinopathy, Springer, New York, NY, 35-63.
https://doi.org/10.1007/978-1-4939-0597-3_2
[7]  Karbwang, J. and White, N.J. (1990) Clinical Pharmacokinetics of Mefloquine. Clinical Pharmacokinetics, 19, 264-279.
https://doi.org/10.2165/00003088-199019040-00002
[8]  Mereddy, G.R., Chakradhar, A., Rutkoski, R.M. and Jonnalagadda, S.C. (2018) Benzoboroxoles: Synthesis and Applications in Medicinal Chemistry. Journal of Organometallic Chemistry, 865, 12-22.
https://doi.org/10.1016/j.jorganchem.2018.03.017
[9]  Adamczyk-Woźniak, A., Borys, K.M. and Sporzyński, A. (2015) Recent Developments in the Chemistry and Biological Applications of Benzoxaboroles. Chemical Reviews, 115, 5224-5247.
https://doi.org/10.1021/cr500642d
[10]  Zhang, J., Zhu, M., Lin, Y. and Zhou, H. (2013) The Synthesis of Benzoxaboroles and Their Applications in Medicinal Chemistry. Science China Chemistry, 56, 1372-1381.
https://doi.org/10.1007/s11426-013-4981-y
[11]  Ponaire, S., Zinglé, C., Tritsch, D., Grosdemange-Billiard, C. and Rohmer, M. (2012) Growth Inhibition of Mycobacterium Smegmatis by Prodrugs of Deoxyxylulose Phosphate Reducto-Isomerase Inhibitors, Promising Anti-Mycobacterial Agents. European Journal of Medicinal Chemistry, 51, 277-285.
https://doi.org/10.1016/j.ejmech.2012.02.03
[12]  Pinheiro, L.C.S., Feitosa, L.M., Gandi, M.O., Silveira, F.F. and Boechat, N. (2019) The Development of Novel Compounds Against Malaria: Quinolines, Triazolpyridines, Pyrazolopyridines and Pyrazolopyrimidines. Molecules, 24, Article No. 4095.
https://doi.org/10.3390/molecules24224095
[13]  Senthilraja, P. and Kathiresan, K. (2015) In Vitro Cytotoxicity MTT Assay in Vero, HepG2 and MCF-7 Cell Lines Study of Marine Yeast. Journal of Applied Pharmaceutical Science, 5, 80-84.
https://doi.org/10.7324/JAPS.2015.50313
[14]  Sundersingh, J.A., Ranjitha, J., Rajan, A. and Shankar, V. (2020) Features of the Biochemistry of Mycobacterium Smegmatis, as a Possible Model for Mycobacterium Tuberculosis. Journal of Infection and Public Health, 13, 1255-1264.
https://doi.org/10.1016/j.jiph.2020.06.023

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