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吡咯霉素类天然产物合成及活性研究进展
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Abstract:
自20世纪以来，抗生素耐药性被认为是影响人类健康的重要因素之一，同时对全球经济发展构成了严重威胁。因此，新型抗生素的开发与应用刻不容缓。天然吡咯霉素是从放线菌和链霉菌属的发酵液中分离得到的多卤化代谢物，因其强大的抗菌活性具有成为新型抗菌剂的巨大潜质，受到医药和农药届的广泛关注。概述了吡咯霉素类化合物的分离、生物合成、全合成及其生物活性研究进展。
Since the 20th century, antibiotic resistance has been regarded as one of the important factors af-fecting human health, and has posed a serious threat to global economic development. Therefore, the development and application of new antibiotics is urgent. Natural pyrrolomycinsare polyhalo-genated metabolites isolated from the fermentation broth of Actinomyces and Streptomyces. Be-cause of its significant antibacterial activity and novel chemical structure, it has great potential to become a new type of antibacterial agent, and has received extensive attention in the field of medi-cine and pesticides. The research progress on the isolation, biosynthesis, total synthesis and biolog-ical activity of natural pyrrolomycins was reviewed.
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