Purpose: To develop a new statistical index “percent CTV (clinical target vo-lume) coverage probability” (%CCP), defined as the probability that a specific percent (e.g., 95%) of the CTV can be reliably
covered by the prescription dose, for
evaluating the coverage loss of brain (fractionated) stereotactic radiosurgery (SRS/fSRS) when
the PTV (planning target volume) margin is zero. Methods:The random variable Q for CTV percent coverage was derived using a previously developed
model for CTV random motion that follows a three-dimensional(3D) independent normal distribution with a zero mean and a standard deviation of ????(for translation) or????(for rotation). Assuming both CTV and PTV are spherical with the
References
[1]
Brown, R.A., Roberts, T.S. and Osborn, A.G. (1980) Stereotaxic Frame and Computer Software for CT-Directed Neurosurgical Localization. Investigative Radiology, 15, 308-312. https://doi.org/10.1097/00004424-198007000-00006
[2]
Leksell, L. and Jernberg, B. (1980) Stereotaxis and Tomography a Technical Note. Acta Neurochirurgica, 52, 1-7. https://doi.org/10.1007/BF01400939
[3]
Jaffray, D.A. (2007) Image-Guided Radiation Therapy: From Concept to Practice. Semi-nars in Radiation Oncology, 17, 243-244. https://doi.org/10.1016/j.semradonc.2007.08.001
[4]
Jin, J.-Y., Yin, F.-F., Tenn, S.E., Medin, P.M. and Solberg, T.D. (2008) Use of the BrainLAB ExacTrac X-Ray 6D System in Image-Guided Radiotherapy. Medical Dosimetry, 33, 124-134. https://doi.org/10.1016/j.meddos.2008.02.005
[5]
Yin, F.-F., Das, S., Kirkpatrick, J., Oldham, M., Wang, Z. and Zhou, S.-M. (2006) Physics and Imaging for Targeting of Oligometastases. Seminars in Radiation Oncology, 16, 85-101. https://doi.org/10.1016/j.semradonc.2005.12.004
[6]
Cernica, G., Wang, Z., Malhotra, H., De Boer, S. and Podgorsak, M.B. (2006) Investigation of Gamma Knife Image Registration Errors Resulting from Misalignment between the Patient and the Imaging Axis. Medical Physics, 33, 941-943. https://doi.org/10.1118/1.2179751
[7]
Winston, K.R. and Lutz, W. (1988) Linear Accelerator as a Neurosurgical Tool for Stereotactic Radiosurgery. Neurosurgery, 22, 454-464. https://doi.org/10.1227/00006123-198803000-00002
[8]
Yeung, D., Palta, J., Fontanesi, J. and Kun, L. (1994) Systematic Analysis of Errors in Target Localization and Treatment Delivery in Stereotactic Radiosurgery (SRS). International Journal of Radiation Oncology Biology Physics, 28, 493-498. https://doi.org/10.1016/0360-3016(94)90076-0
[9]
Li, G., Ballangrud, Å., Kuo, L.C., Kang, H., Kirov, A., Lovelock, M., Yamada, Y., Mechalakos, J. and Amols, H. (2011) Motion Monitoring for Cranial Frameless Stereotactic Radiosurgery Using Video-Based Three-Dimensional Optical Surface Imaging. Medical Physics, 38, 3981-3994. https://doi.org/10.1118/1.3596526
[10]
Schell, M.C., Bova, F.J., Larson, D.A., Leavitt, D.D., Lutz, W.R., Podgorsak, E.B. and Wu, A. (1995) Stereotactic Radiosurgery: Report of Task Group 42, AAPM Radiation Therapy Committee American Institute of Physics, Woodbury. https://doi.org/10.37206/53
[11]
Shaw, E., Scott, C., Souhami, L., Dinapoli, R., Kline, R., Loeffler, J. and Farnan, N. (2000) Single Dose Radiosurgical Treatment of Recurrent Previously Irradiated Primary Brain Tumors and Brain Metastases: Final Report of RTOG Protocol 90-05. International Journal of Radiation Oncology Biology Physics, 47, 291-298. https://doi.org/10.1016/S0360-3016(99)00507-6
[12]
Chang, J. (2017) A Statistical Model for Analyzing the Rotational Error of Single Isocenter for Multiple Targets Technique. Medical Physics, 44, 2115-2123. https://doi.org/10.1002/mp.12262
