%0 Journal Article
%T A Statistical Index for Evaluating the CTV Coverage Loss of Brain Stereotactic Radiosurgery When the PTV Margin Is Zero
%A Jenghwa Chang
%J International Journal of Medical Physics,Clinical Engineering and Radiation Oncology
%P 84-97
%@ 2168-5444
%D 2022
%I Scientific Research Publishing
%R 10.4236/ijmpcero.2022.111008
%X <b><span style=\"font-family:;\" \"=\"\">Purpose: </span></b><span style=\"font-family:;\" \"=\"\">To develop a new statistical index ˇ°percent CTV (clinical target</span><span><span style=\"font-family:;\" \"=\"\"> vo</span></span><span><span style=\"font-family:;\" \"=\"\">-</span></span><span><span style=\"font-family:;\" \"=\"\">lume) coverage probability</span></span><span style=\"font-family:;\" \"=\"\">ˇ± (%CCP), defined as the probability that a specific <span>percent (e.g., 95%) of the CTV can be reliably
covered by the prescription</span> dose, <span>for
evaluating the coverage loss of brain (fractionated) stereotactic</span> radiosurgery (SRS/</span><span style=\"font-family:;\" \"=\"\">f</span><span style=\"font-family:;\" \"=\"\">SRS) when
the PTV (planning target volume) margin is zero. <b>Methods:</b> <span>The random variable <i>Q</i> for CTV percent coverage was derived using a</span> pre<span>viously </span><span>developed
model for CTV random motion that follows a three-dimensional</span> <span>(3D) independent normal distribution with </span></span><span style=\"font-family:;\" \"=\"\">a </span><span style=\"font-family:;\" \"=\"\">zero mean and </span><span style=\"font-family:;\" \"=\"\">a </span><span style=\"font-family:;\" \"=\"\">standard</span><span style=\"font-family:;\" \"=\"\"> de<span>via</span><span>tion of </span></span><span style=\"font-size:12.0pt;font-family:;\" \"=\"\"><span style=\"white-space:nowrap;\"><span style=\"white-space:nowrap;\"><span style=\"white-space:nowrap;\"><span style=\"white-space:nowrap;\">??</span></span></span></span></span><sub><span style=\"font-size:9.0pt;font-family:;\" \"=\"\"><span style=\"white-space:nowrap;\"><span style=\"white-space:nowrap;\"><span style=\"white-space:nowrap;\"><span style=\"white-space:nowrap;\">??</span></span></span></span></span></sub><span style=\"font-family:;\" \"=\"\">(for translation) </span><span style=\"font-family:;\" \"=\"\">or</span><span style=\"font-family:;\" \"=\"\"> </span><span style=\"font-size:14.0pt;font-family:;\" \"=\"\"><span style=\"white-space:nowrap;\"><span style=\"font-size:18.6667px;\"><span style=\"white-space:nowrap;\"><span style=\"font-size:16px;\">??</span></span></span></span></span><sub><span style=\"font-size:10.5pt;font-family:;\" \"=\"\"><span style=\"white-space:nowrap;\"><span style=\"white-space:nowrap;\"><span style=\"white-space:nowrap;\">??</span></span></span></span></sub><span style=\"font-family:;\" \"=\"\">(for rotation). Assuming both CTV and </span><span style=\"font-family:;\" \"=\"\">PTV are spherical with the
%K Stereotactic Radiosurgery
%K PTV Margin
%K Coverage Probability
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=115538