Rationale: Patients with cancer commonly experience dyspnea originating from ventilatory, circulatory and musculoskeletal
sources, and dyspnea is best determined by
cardiopulmonary exercise testing (CPET). Objectives: In this
retrospective pilot study, we
evaluated patients with hematologic and solid malignancies by CPET to determine
the primary source of their dyspnea. Methods: Subjects were exercised on
a cycle ergometer with increasing workloads. Minute ventilation, heart rate,
breathing reserve, oxygen uptake (V’O2), O2-pulse,
ventilatory equivalents for carbon dioxide and oxygen (V’E/V’CO2 and V’E/V’O2, respectively) were measured at baseline and
peak exercise. The slope and intercept for V’E/V’CO2 was
computed for all subjects. Peak V’O2 <84% predicted indicated a circulatory or ventilatory
limitation.
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