%0 Journal Article
%T Dead Space Breathing in Patients with Malignancies: Determination by Cardiopulmonary Exercise Testing
%A Harrison Ngue
%A Maranda Ngue
%A Ian Lee
%A Ching-Fei Chang
%A Ahmet Baydur
%J Open Journal of Respiratory Diseases
%P 15-36
%@ 2163-9418
%D 2022
%I Scientific Research Publishing
%R 10.4236/ojrd.2022.121002
%X Rationale: Patients with cancer commonly experience dyspnea originating from ventilatory, circulatory and musculoskeletal
sources, and dyspnea is best determined by
cardiopulmonary exercise testing (CPET). Objectives: In this
retrospective pilot study, we
evaluated patients with hematologic and solid malignancies by CPET to determine
the primary source of their dyspnea. Methods: Subjects were exercised on
a cycle ergometer with increasing workloads. Minute ventilation, heart rate,
breathing reserve, oxygen uptake (V¡¯O2), O2-pulse,
ventilatory equivalents for carbon dioxide and oxygen (V¡¯E/V¡¯CO2 and V¡¯E/V¡¯O2, respectively) were measured at baseline and
peak exercise. The slope and intercept for V¡¯E/V¡¯CO2 was
computed for all subjects. Peak V¡¯O2 <84% predicted indicated a circulatory or ventilatory
limitation.