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血清镁离子与2型糖尿病及其并发症相关性研究进展
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Abstract:
2型糖尿病发病率逐年升高，其并发症常常严重危害人们的健康，镁离子是人体内重要的阳离子，参与人体内多种酶联反应。已经有研究表明人体内血清镁离子水平的变化参与2型糖尿病的发生发展，近年来还有研究发现血清镁离子水平的变化与2型糖尿病的并发症如视网膜病变、糖尿病肾病和心血管并发症的发生有关，近几年也有关于利用镁剂治疗2型糖尿病及其并发症的研究。本文就镁离子在2型糖尿病及其并发症中的作用研究作一综述，为未来2型糖尿病的治疗提供新的思路。
The incidence of type 2 diabetes is increasing year by year, and its complications often seriously harm people’s health. Magnesium ion is an important cation in human body and participates in a variety of enzyme linked reactions in human body. Research has shown that the change of serum level of magnesium ions in the human body participates in the development of type 2 diabetes, and in recent years the study found that the change of the serum magnesium levels is related to the type 2 diabetes complications such as retinopathy, diabetic nephropathy, and associated cardiovascular complications. And there are also studies on the use of magnesium in the treatment of type 2 diabetes and its complications. This article reviews the role of magnesium ion in type 2 diabetes and its complications, and provides new ideas for the treatment of type 2 diabetes in the future.
| [1] | 吕若琦. 最新版“全球糖尿病地图”里的中国景象[J]. 江苏卫生保健, 2020(2): 56. |
| [2] | Ozcaliskan, I.H., Sahin, H., Tanriverdi, F., et al. (2019) Association between Magnesium Status, Dietary Magnesium Intake, and Metabolic Control in Patients with Type 2 Diabetes Mellitus. The Journal of the American College of Nutrition, 38, 31-39. https://doi.org/10.1080/07315724.2018.1476194 |
| [3] | 郭林池, 付传芳, 詹晓蓉. 镁离子、钾离子与2型糖尿病的相关性研究[J]. 哈尔滨医科大学学报, 2019, 53(2): 171-173. |
| [4] | Veronese, N., Watutantrige-Fernando, S., Luchini, C., et al. (2016) Effect of Magnesium Supplementation on Glucose Metabolism in People with or at Risk of Diabetes: A Systematic Review and Meta-Analysis of Double-Blind Randomized Controlled Trials. European Journal of Clinical Nutrition, 70, 1354-1359. https://doi.org/10.1038/ejcn.2016.154 |
| [5] | Spiga, R., Mannino, G.C., Mancuso, E., et al. (2019) Are Circulating Mg2+ Levels Associated with Glucose Tolerance Profiles and Incident Type 2 Diabetes? Nutrients, 11, 2460. https://doi.org/10.3390/nu11102460 |
| [6] | Rehman, K. and Akash, M.S.H. (2017) Mechanism of Generation of Oxidative Stress and Pathophysiology of Type 2 Diabetes Mellitus: How Are They Interlinked? Journal of Cellular Biochemistry, 118, 3577-3585.
https://doi.org/10.1002/jcb.26097 |
| [7] | Zheltova, A.A., Kharitonova, M.V., Iezhitsa, I.N., et al. (2016) Magnesium Deficiency and Oxidative Stress: An Update. Biomedicine (Taipei), 6, 20. https://doi.org/10.7603/s40681-016-0020-6 |
| [8] | Gommers, L.M., Hoenderop, J.G., Bindels, R.J., et al. (2016) Hypomagnesemia in Type 2 Diabetes: A Vicious Circle? Diabetes, 65, 3-13. https://doi.org/10.2337/db15-1028 |
| [9] | Günther, T. (2010) The Biochemical Function of Mg2+ in Insulin Secretion, Insulin Signal Transduction and Insulin Resistance. Magnesium Research, 23, 5-18. https://doi.org/10.1684/mrh.2009.0195 |
| [10] | Akaya, J., Higashino, H. and Kobayashi, Y. (2004) Intracellular Magnesium and Insulin Resistance. Magnesium Research, 17, 126-136. |
| [11] | Wu, J., Xun, P., Tang, Q., et al. (2017) Circulating Magnesium Levels and Incidence of Coronary Heart Diseases, Hypertension, and Type 2 Diabetes Mellitus: A Meta-Analysis of Prospective Cohort Studies. Nutrition Journal, 16, 60.
https://doi.org/10.1186/s12937-017-0280-3 |
| [12] | Romani, A.M., Matthews, V.D. and Scarpa, A. (2000) Parallel Stimulation of Glucose and Mg(2+) Accumulation by Insulin in Rat Hearts and Cardiac Ventricular Myocytes. Circulation Research, 86, 326-333.
https://doi.org/10.1161/01.RES.86.3.326 |
| [13] | Ashcroft, F.M., Puljung, M.C. and Vedovato, N. (2017) Neonatal Diabetes and the KATP Channel: From Mutation to Therapy. Trends in Endocrinology & Metabolism, 28, 377-387. https://doi.org/10.1016/j.tem.2017.02.003 |
| [14] | Lima Mde, L., Cruz, T., Rodrigues, L.E., et al. (2009) Serum and Intracellular Magnesium Deficiency in Patients with Metabolic Syndrome—Evidences for Its Relation to Insulin Resistance. Diabetes Research and Clinical Practice, 83, 257-262. https://doi.org/10.1016/j.diabres.2008.11.019 |
| [15] | Yang, N., He, L., Li, Y., et al. (2020) Reduced Insulin Resistance Partly Mediated the Association of High Dietary Magnesium Intake with Less Metabolic Syndrome in a Large Chinese Population. Diabetes, Metabolic Syndrome and Obesity, 13, 2541-2550. https://doi.org/10.2147/DMSO.S257884 |
| [16] | Zhang, Y., Li, Q., Xin, Y., et al. (2018) Association between Serum Magnesium and Common Complications of Diabetes Mellitus. Technology and Health Care, 26, 379-387. https://doi.org/10.3233/THC-174702 |
| [17] | Joy, S.S., George, T.P. and Siddiqui, K. (2019) Low Magnesium Level as an Indicator of Poor Glycemic Control in Type 2 Diabetic Patients with Complications. Diabetology & Metabolic Syndrome, 13, 1303-1307.
https://doi.org/10.1016/j.dsx.2019.02.001 |
| [18] | Farrokhian, A., Bahmani, F., Taghizadeh, M., et al. (2016) Selenium Supplementation Affects Insulin Resistance and Serum hs-CRP in Patients with Type 2 Diabetes and Coronary Heart Disease. Hormone and Metabolic Research, 48, 263-268. https://doi.org/10.1055/s-0035-1569276 |
| [19] | Navarro-González, J.F., Mora-Fernández, C., Muros de Fuentes, M., et al. (2011) Inflammatory Molecules and Pathways in the Pathogenesis of Diabetic Nephropathy. Nature Reviews Nephrology, 7, 327-340.
https://doi.org/10.1038/nrneph.2011.51 |
| [20] | Liu, M., Jeong, E.M., Liu, H., et al. (2019) Magnesium Supplementation Improves Diabetic Mitochondrial and Cardiac Diastolic Function. JCI Insight, 4, e123182. https://doi.org/10.1172/jci.insight.123182 |
| [21] | Feng, J., Wang, H., Jing, Z., et al. (2021) Relationships of the Trace Elements Zinc and Magnesium with Diabetic Nephropathy-Associated Renal Functional Damage in Patients with Type 2 Diabetes Mellitus. Frontiers in Medicine (Lausanne), 8, Article ID: 626909. https://doi.org/10.3389/fmed.2021.626909 |
| [22] | Bherwani, S., Jibhkate, S.B., Saumya, A.S., et al. (2017) Hypomagnesaemia: A Modifiable Risk Factor of Diabetic Nephropathy. Hormone Molecular Biology and Clinical Investigation, 29, 79-84.
https://doi.org/10.1515/hmbci-2016-0024 |
| [23] | Wang, W. and Lo, A.C.Y. (2018) Diabetic Retinopathy: Pathophysiology and Treatments. International Journal of Molecular Sciences, 19, 1816. https://doi.org/10.3390/ijms19061816 |
| [24] | Brownlee, M. (2005) The Pathobiology of Diabetic Complications: A Unifying Mechanism. Diabetes, 54, 1615-1625.
https://doi.org/10.2337/diabetes.54.6.1615 |
| [25] | Yuuki, T., Kanda, T., Kimura, Y., et al. (2001) Inflammatory Cytokines in Vitreous Fluid and Serum of Patients with Diabetic Vitreoretinopathy. Journal of Diabetic Complications, 15, 257-259.
https://doi.org/10.1016/S1056-8727(01)00155-6 |
| [26] | Mahajan, N., Arora, P. and Sandhir, R. (2019) Perturbed Biochemical Pathways and Associated Oxidative Stress Lead to Vascular Dysfunctions in Diabetic Retinopathy. Oxidative Medicine and Cellular Longevity, 2019, Article ID: 8458472. https://doi.org/10.1155/2019/8458472 |
| [27] | Wu, Y., Tang, L. and Chen, B. (2014) Oxidative Stress: Implications for the Development of Diabetic Retinopathy and Antioxidant Therapeutic Perspectives. Oxidative Medicine and Cellular Longevity, 2014, Article ID: 752387.
https://doi.org/10.1155/2014/752387 |
| [28] | Hamdan, H.Z., Nasser, N.M., Adam, A.M., et al. (2015) Serum Magnesium, Iron and Ferritin Levels in Patients with Diabetic Retinopathy Attending Makkah Eye Complex, Khartoum, Sudan. Biological Trace Element Research, 165, 30-34. https://doi.org/10.1007/s12011-015-0236-4 |
| [29] | Dasgupta, A., Sarma, D. and Saikia, U.K. (2012) Hypomagnesemia in Type 2 Diabetes Mellitus. Indian Journal of Endocrinology and Metabolism, 16, 1000-1003. https://doi.org/10.4103/2230-8210.103020 |
| [30] | De Leeuw, I., Engelen, W., De Block, C., et al. (2004) Long Term Magnesium Supplementation Influences Favourably the Natural Evolution of Neuropathy in Mg-Depleted Type 1 Diabetic Patients (T1dm). Magnesium Research, 17, 109-114. |
| [31] | Afzali, H., Jafari Kashi, A.H., Momen-Heravi, M., et al. (2019) The Effects of Magnesium and Vitamin E Co-Supplementation on Wound Healing and Metabolic Status in Patients with Diabetic Foot Ulcer: A Randomized, Double-Blind, Placebo-Controlled Trial. Wound Repair and Regeneration, 27, 277-284.
https://doi.org/10.1111/wrr.12701 |
| [32] | Zhang, X., Yan, S.M., Zheng, H.L., et al. (2014) A Mechanism Underlying Hypertensive Occurrence in the Metabolic Syndrome: Cooperative Effect of Oxidative Stress and Calcium Accumulation in Vascular Smooth Muscle Cells. Hormone and Metabolic Research, 46, 126-132. https://doi.org/10.1055/s-0033-1355398 |
| [33] | Maier, J.A., Castiglioni, S., Locatelli, L., et al. (2021) Magnesium and Inflammation: Advances and Perspectives. Seminars in Cell and Developmental Biology, 115, 37-44. https://doi.org/10.1016/j.semcdb.2020.11.002 |
| [34] | Agrawal, P., Arora, S., Singh, B., et al. (2011) Association of Macrovascular Complications of Type 2 Diabetes Mellitus with Serum Magnesium Levels. Diabetes & Metabolic Syndrome, 5, 41-44.
https://doi.org/10.1016/j.dsx.2010.12.003 |
| [35] | Ramadass, S., Basu, S. and Srinivasan, A.R. (2015) Serum Magnesium Levels as an Indicator of Status of Diabetes Mellitus Type 2. Diabetology & Metabolic Syndrome, 9, 42-45. https://doi.org/10.1016/j.dsx.2014.04.024 |
| [36] | Rashvand, S., Mobasseri, M. and Tarighat-Esfanjani, A. (2019) The Effects of Choline and Magnesium Co-Supplementation on Metabolic Parameters, Inflammation, and Endothelial Dysfunction in Patients with Type 2 Diabetes Mellitus: A Randomized, Double-Blind, Placebo-Controlled Trial. The Journal of the American College of Nutrition, 38, 714-721.
https://doi.org/10.1080/07315724.2019.1599745 |
