This work, contains some new compounds from benzimidazole derivatives, which are synthesized by condensation of Orthophenylene
diamine and Carbon disulfide resulting in 2-Mercapto-benzimidazole
which is treated by alcoholic potassium hydroxide forming
potassium salt of 2-mercaptobenzimidazole which reacts with different
substances (alkyl chloroacetates, chloroacetic chloride, alkyl halides)
also the ethoxy carbonyl methyl thiobenzimidazole reacts with different amines.
In addition to chloromethyl benzimidazole which resulted from the reaction
between orthophenylene diamine and chloroacetic acid, which reacted with
different amines. The synthesized compound tested as analgesics and anticancer
activity the new derivatives revealed moderate, strong and very strong
analgesics and moderate and strong anticancer activity.
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