%0 Journal Article
%T Design, Synthesis of Analgesics and Anticancer of Some New Derivatives of Benzimidazole
%A Helmy M. Sakr
%A Rezk R. Ayyad
%A Kazem Mahmoud
%A Ahmed M. Mansour
%A Ahmed. G Ahmed
%J International Journal of Organic Chemistry
%P 144-169
%@ 2161-4695
%D 2021
%I Scientific Research Publishing
%R 10.4236/ijoc.2021.113011
%X T<span style=\"font-family:Verdana;\">his work, contain</span><span style=\"font-family:Verdana;\">s</span><span style=\"font-family:Verdana;\"> some new compounds from benzimidazole derivatives, which </span><span style=\"font-family:Verdana;\">are </span><span style=\"font-family:Verdana;\">synthesized by condensation of Orthophenylene
diamine and Carbon disulfide resulting </span><span style=\"font-family:Verdana;\">in </span><span style=\"font-family:Verdana;\">2-Mercapto-benzimidazole
which </span><span style=\"font-family:Verdana;\">is </span><span style=\"font-family:Verdana;\">treated by alcoholic potassium hydroxide forming
potassium salt of 2-mercaptobenzimidazole which reacts with different
substances (alkyl chlo</span><span style=\"font-family:Verdana;\">roacetates, chloroacetic chloride, alkyl halides)
also the ethoxy carbonyl methyl thiobenzimidazole reacts with different amines.
In addition to chloromethyl benzimidazole which resulted from the reaction
between orthophenylene diamine and chloroacetic acid, which reacted with
different amines. The synthesized compound tested as analgesics and anticancer
activity the new derivatives revealed moderate, strong and very strong
analgesics and moderate and strong anticancer activity</span><span style=\"font-family:Verdana;\">.</span>
%K Benzimidazole
%K Analgesics and Anticancer
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=112320