A Baseline Studies on the Nutritional Interplay between HIV Drugs and Kidney, Liver and Heart Indices in Patients Receiving HIV Treatment in North-East Nigeria
Human Immunodeficiency Virus (HIV) patients on Antiretroviral Therapy (ART)
have shown impressive improvement and death rates have drastically reduced,
even though complications still exist. This research carried out a baseline
study to determine the nutritional interplay between HIV-drugs and kidney,
liver, and heart indices among subjects undergoing HIV treatment and attending the Medical Out-Patient Department of a Federal Medical Center in the North-Eastern part of Nigeria, using a sample size of 50 individuals both male
and female, who have been shown to be HIV positive and have been on ART for
over 12 months.Anthropometric data was collected in
triplicate, two from patients’ file,
and one was measured directly and the average was obtained. The electrolytes were determined by the colorimetric method while total protein and albumin in blood
concentration were determined by spectrophotometric method, but globulin and
A/G ratio were determined by calculation. TC
was determined usingSpectrophotometric
method while HDL was determined after precipitation of LDL with
phosphotungstate and magnesium were
References
[1]
UNAIDS (Joint United Nations Programme on HIV/AIDS) (2019) Global HIV & AIDS Statistics—2019 Fact Sheet. https://www.unaids.org/en/resources/fact-sheet
[2]
http://www.statistica.com
[3]
UNAIDS (2008) Nigeria Country Profile.
[4]
UNAIDS (Joint United Nations Programme on HIV/AIDS) (2019) Press Release of a New Survey Results Indicate That Nigeria Has an HIV Prevalence of 1.4%. https://www.unaids.org/en/resources/presscentre/pressreleaseandstatementarchive/2019/march/20190314_nigeria
[5]
Priscilla, Y., Hsue, M.D., David, D. and Waters, M.D. (2005) What a Cardiologist Needs to Know about Patient with HIV Infection. Circulation, 112, 3947-3957. https://doi.org/10.1161/CIRCULATIONAHA.105.546465
[6]
Zhang, Y.Z., Li, H.J., Cheng, J.L., Wu, H. and Bao, D.Y. (2011) Computed Tomographic Demonstrations of HIV Seropositive Pulmonary Tuberculosis and Their Relationship with CD4+ T-Lymphocyte Count. Chinese Medical Journal, 124, 693-698.
[7]
Schwartz, S.A. and Nair, M.P.N. (1999) Current Concepts in Human Immunodeficiency Virus Infection and AIDS. Clinical and Diagnostic Laboratory Immunology, 6, 295-305. https://doi.org/10.1128/CDLI.6.3.295-305.1999
[8]
World Health Organisation (2019) Newsroom Fact Sheet on HIV/AIDS for 25th July 2019. https://www.who.int/news-room/fact-sheets/detail/hiv-aids
[9]
Igwe, K.O., Ujowundu, C.O., Chieme, S.C. and Obasi, U.K. (2020) Serum Protein Status and Electrolyte Profile of HIV/AIDS Patients on HAART in UPTH, Rivers State—Nigeria. African Journal of Biological Sciences, 2, 88-93. https://doi.org/10.33472/AFJBS.2.3.2020.88-93
[10]
Nwauche, K.T., Agomuo, E.N., Anacletus, F.C. and Nwosu, G.U. (2019) Comparative Study on the Electrolyte Levels of HIV/AIDS Patients on High Active Antiretroviral Therapy (HAART) in Owerri Metropolis, South Eastern Nigeria. International STD Research & Reviews, 8, 1-5. https://doi.org/10.9734/ISRR/2019/v8i230101
[11]
Doumas, B.T., Watson, W.A. and Biggs, H.G. (1971) Albumin Standards and the Measurement of Serum Albumin with Bomocresol Green. Clinica Chimica Acta, 31, 87-96. https://doi.org/10.1016/0009-8981(71)90365-2
Friedwald, W.T., Levy, R.I. and Frederickson, D.S. (1972) Estimationof the Concentration of Low Density Lipoproteincholesterol in Plasma without Use of Preparative Ultracentrifugation. Clinical Chemistry, 18, 499-502. https://doi.org/10.1093/clinchem/18.6.499
[14]
Bhimavarapu, R., Chitra, K.P., Ramaswamy, M., Karunakaran, P., Reddy, A.B. and Rani, B.S. (2010) Nutritional Status and Serum Zinc Levels in HIV Infected Individuals Compared to Control Subjects Undergoing Anti Retro Viral Therapy (ART). Journal of Pharmaceutical Sciences and Research, 2, 745-751.
[15]
Baum, M.K., Shor-Posne, G. and Campa, A. (2000) Zinc Status in Human Immunodeficiency Virus Infection. Journal of Nutrition, 130, 1421S-1423S.