Objective: To
evaluate the benefit of dual trigger (hCG + GnRH agonist) in patients underwent
controlled ovarian stimulation for IVF in an antagonist protocol. Methods: A retrospective case control study
was performed (January 2017 to March 2019) in a single IVF center. The dual
trigger group (n = 17), ovulation trigger was achieved with both hCG and GnRH
agonist while in the single trigger group (n = 34), it was achieved by hCG
alone. The first endpoint was the number of mature oocytes retrieved; the
secondary endpoints were total number of oocytes retrieved, the number of
cleaved embryos obtained (day 3) and blastocysts (day 5/day 6), the number of
embryos transferred, the ongoing-pregnancy/miscarriage rate. Results: The dual vs. the single group
showed the followings. The number of retrieved oocytes of 7.1 vs. 6.4 (p =
0.68); mature oocytes of 4.6 vs. 4.1 (p = 0.62), day-3-embryos of 2.9 vs. 2.0
(p = 0.2), day-5/6-embryos of 0.3 vs. 0.03 (p = 0.13), transferred embryos of
2.1 vs. 1.8 (p = 0.48); ongoing pregnancy of 1 vs. 9 (p = 0.14); miscarriage of
0 vs. 2 (p = 1). Conclusion: A dual trigger showed no additional clinical benefits. Future large studies are
needed to demonstrate a real clinical advantage.
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