%0 Journal Article
%T Dual Trigger in <i>in Vitro</i> Fertilization: A Case-Control Study
%A Yassir Ait Benkaddour
%A Achraf Douazi
%A Karam Harou
%A Abderraouf Soummani
%J Open Journal of Obstetrics and Gynecology
%P 1064-1072
%@ 2160-8806
%D 2021
%I Scientific Research Publishing
%R 10.4236/ojog.2021.118099
%X <strong><em>Objective</em></strong><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\">:</span></span></span><span><span><span style=\"font-family:&quot;\"><span style=\"font-family:Verdana;\"> To
evaluate the benefit of dual trigger (hCG + GnRH agonist) in patients underwent
controlled ovarian stimulation for IVF in an antagonist protocol. </span><b><i><span style=\"font-family:Verdana;\">Methods</span></i></b><span style=\"font-family:Verdana;\">:</span><span style=\"font-family:Verdana;\"> A retrospective case control study
was performed (January 2017 to March 2019) in a single IVF center. The dual
trigger group (n = 17), ovulation trigger was achieved with both hCG and GnRH
agonist while in the single trigger group (n = 34), it was achieved by hCG
alone. The first endpoint was the number of mature oocytes retrieved; the
secondary endpoints were total number of oocytes retrieved, the number of
cleaved embryos obtained (day 3) and blastocysts (day 5/day 6), the number of
embryos transferred, the ongoing-pregnancy/miscarriage rate. </span><b><i><span style=\"font-family:Verdana;\">Results</span></i></b><span style=\"font-family:Verdana;\">:</span><span style=\"font-family:Verdana;\"> The dual vs. the single group
showed the followings. The number of retrieved oocytes of 7.1 vs. 6.4 (p =
0.68); mature oocytes of 4.6 vs. 4.1 (p = 0.62), day-3-embryos of 2.9 vs. 2.0
(p = 0.2), day-5/6-embryos of 0.3 vs. 0.03 (p = 0.13), transferred embryos of
2.1 vs. 1.8 (p = 0.48); ongoing pregnancy of 1 vs. 9 (p = 0.14); miscarriage of
0 vs. 2 (p = 1). </span><b><i><span style=\"font-family:Verdana;\">Conclusion</span></i></b><span style=\"font-family:Verdana;\">:</span><span style=\"font-family:Verdana;\"> A dual trigger showed no additional clinical benefits. Future large studies are
needed to demonstrate a real clinical advantage.</span></span></span></span>
%K Chorionic Gonadotropin
%K GnRH Agonist
%K Dual Trigger
%K &lt
%K i&gt
%K In Vitro&lt
%K /i&gt
%K Fertilization
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=111513