Background: Preeclampsia (PE) is still one of the leading causes of maternal/perinatal
morbidity/mortality in Nigeria. Imbalance between placenta growth factor (PLGF)
and soluble fms-like tyrosine kinase 1 (sFlt1) has been reportedly present both
before and after the manifestation of PE;
however, Nigerian data regarding these angiogenesis-related substances are
lacking. We here attempted to determine the maternal serum level of PLGF and
sFlt1 and sFlt1/PLGF ratio in PE vs. non-PE women in Lagos State University
Teaching Hospital, Nigeria.Methods: An observational cross-sectional study was made on 75 women with
PE and 75 age-gestational-age matched women without PE, as case and control,
respectively. Levels of sFlt-1, PIGF and the sFlt-1: PIGF ratio was compared
between the two. Results: Serum levels of Flt-1 and sFlt1/PIGF ratio were
significantly higher in PE patients (6581.86 ± 865.75, and 146.42 ± 92.43) than
in the normotensive control (4584.52 ± 1479.6 and 11.60 ± 6.42). PIGF was
significantly lower in PE patients (70.14 ± 51.03) than the normotensives
(494.06 ± 475.8). There were positive and negative correlations between
the sFlt-1 and PLGF respectively and mean arterial blood pressure. Conclusion:
Serum sFlt-1, sFlt1/PIGF ratio was significantly higher and PIGF levels were significantly lower in PE than normotensive control in Nigerian population.
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