%0 Journal Article
%T Placenta Growth Factor and Soluble Fms-Like Tyrosine Kinase 1 in Preeclampsia and Normotensive Pregnant Nigerian Women
%A Abidoye Gbadegesin
%A Joy O. Agbara
%A Kabiru A. Rabiu
%A Adekunle A. Sobande
%A Madinah A. Azeez
%J Open Journal of Obstetrics and Gynecology
%P 753-762
%@ 2160-8806
%D 2021
%I Scientific Research Publishing
%R 10.4236/ojog.2021.116070
%X Background: Preeclampsia (PE) is still one of the leading causes of maternal/perinatal
morbidity/mortality in Nigeria. Imbalance between placenta growth factor (PLGF)
and soluble fms-like tyrosine kinase 1 (sFlt1) has been reportedly present both
before and after the manifestation <span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\">of </span></span></span><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\">PE;
however, Nigerian data regarding these angiogenesis-related substances are
lacking. We here attempted to determine the maternal serum level of PLGF and
sFlt1 and sFlt1/PLGF ratio in PE vs. non-PE women in Lagos State University
Teaching Hospital, Nigeria.</span></span></span><span><span><span style=\"font-family:;\" \"=\"\"> </span></span></span><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\">Methods: An observational cross-sectional study was made on 75 women with
PE and 75 age-gestational-age matched women without PE, as case and control,
respectively. Levels of sFlt-1, PIGF and the sFlt-1: PIGF ratio was compared
between the two. Results: Serum levels of Flt-1 and sFlt1/PIGF ratio were
significantly higher in PE patients (6581.86 ¡À 865.75, and 146.42 ¡À 92.43) than
in the normotensive control (4584.52 ¡À 1479.6 and 11.60 ¡À 6.42). PIGF was
significantly lower in PE patients (70.14 ¡À 51.03) than the normotensives
(494.06 ¡À 475.8). There were positive and negative correlation</span></span></span><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\">s</span></span></span><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"> between
the sFlt-1 and PLGF respectively and mean arterial blood pressure. Conclusion:
Serum sFlt-1, sFlt1/PIGF ratio was significantly higher and PIGF levels </span></span></span><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\">were </span></span></span><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\">significantly lower in PE than normotensive control in Nigerian population</span></span></span><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\">.</span></span></span>
%K Preeclampsia
%K Soluble Fms-Like Tyrosine Kinase 1 (sFlt-1)
%K Placental Growth Factor (PlGF)
%K Pregnancy
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=109910