The effect of lung ventilation on total oxidative condition, total antioxidant capacity and oxidative stress index during cardiopulmonary bypass

Background:The aim in this study is to obtain the necessity of pulmonary ventilation during cardiopulmonary bypass by starting respiration of a group of patients with 10% volume and the other group stopping respiration totally as well as by examining TAS (Total Antioxidant Status), TOS (Total oxidative status), OS？ (oxidative stress index) in pre-op and after bypass. Methods:Totally 30 patients (14 M+ 16 F) that had cardiopulmonary bypass surgery in Thoracic and Cardiovascular Surgery Department for various reasons, were chosen. The patients were seperated into 2 groups (as pulmonary respiration was stopped completely and pulmonary respiration was started by 10% cc volume). Before carrdiopulmonary bypass working group was formed among patients seperated into 2 groups by taking totally 4 tubes of blood before cardiopulmonary bypass, at pump inlet, pump outlet and after operation. After eluting taken blood in centrifuge, they were kept at -80 °C. Then TAS, TOS and OS？ were studied by using Erel method. ResultsTAS value was found as 1,0945±0,25, TOS value as 15,38±6,10 and OSi value was found as 1,4827±0,67. TAS value of unventilated patients was found as 1,1514±0,24, TOS value was as 25,73±9,25 and OSi value was found as 2,2993±0,85. TOS value in patients increased in unventilated patients. The increase in TOS value in our study did not form any change on TAS value however there occured a significant difference on OS？ value. (p<0.05) Conclusions: As two groups were compared there did not occur a significant difference on TAS value, there came out a significant result in terms of TOS and OS？ values. During CPB, TOS and OS？ values of unventilated patients were found high and significant compared to 10% ventilated patients. This situation shows that oxidative stress parameters in 10% ventilated patients decreases during CPB