%0 Journal Article
%T The effect of lung ventilation on total oxidative condition, total antioxidant capacity and oxidative stress index during cardiopulmonary bypass
%A Mahmut PADAK
%J -
%D 2019
%X Background:The aim in this study is to obtain the necessity of pulmonary ventilation during cardiopulmonary bypass by starting respiration of a group of patients with 10% volume and the other group stopping respiration totally as well as by examining TAS (Total Antioxidant Status), TOS (Total oxidative status), OS£¿ (oxidative stress index) in pre-op and after bypass. Methods:Totally 30 patients (14 M+ 16 F) that had cardiopulmonary bypass surgery in Thoracic and Cardiovascular Surgery Department for various reasons, were chosen. The patients were seperated into 2 groups (as pulmonary respiration was stopped completely and pulmonary respiration was started by 10% cc volume). Before carrdiopulmonary bypass working group was formed among patients seperated into 2 groups by taking totally 4 tubes of blood before cardiopulmonary bypass, at pump inlet, pump outlet and after operation. After eluting taken blood in centrifuge, they were kept at -80 ¡ãC. Then TAS, TOS and OS£¿ were studied by using Erel method. ResultsTAS value was found as 1,0945¡À0,25, TOS value as 15,38¡À6,10 and OSi value was found as 1,4827¡À0,67. TAS value of unventilated patients was found as 1,1514¡À0,24, TOS value was as 25,73¡À9,25 and OSi value was found as 2,2993¡À0,85. TOS value in patients increased in unventilated patients. The increase in TOS value in our study did not form any change on TAS value however there occured a significant difference on OS£¿ value. (p<0.05) Conclusions: As two groups were compared there did not occur a significant difference on TAS value, there came out a significant result in terms of TOS and OS£¿ values. During CPB, TOS and OS£¿ values of unventilated patients were found high and significant compared to 10% ventilated patients. This situation shows that oxidative stress parameters in 10% ventilated patients decreases during CPB
%K Kardiyopulmoner baypas
%K Oksidatif stres
%K Antioksidanlar
%K Oksidatif stres
%U http://dergipark.org.tr/hutfd/issue/44085/444164