Investigation of the IL-1 β Genotype and its Levels on Patients Treated with Osteointegrated Dental Implants

DOI: 10.26650/experimed.2019.19002 Objective: In our study, we aimed to investigate the relationship between the Interleukin-1β (IL-1β) +3953 gene polymorphism, the levels of this interleukin and smoking in osteointegrated dental implant losses. Materials and Methods: 56 patients with implants and 238 healthy control subjects were included in this study. PCR and RFLP methods was used to determine the IL-1β +3953 gene polymorphisms. Serum IL-1β levels were measured using ELISA. Results: The IL-1β +3953 CC, TT and CT genotype frequencies for the controls and study cases were 61.2%, 10.1% ,43.6%, and 48.2%, 8.9% and 42.9%, respectively. IL-1β +3953 T allele carriers increased more in the patient group (51.8%) compared to the control group (38.8%). These cases also had an increased plaque index, bleeding index, pocket deepness and serum IL-1β levels, but none of them were statistically significant (p>0.05). Implant losses were more frequent in C allele carriers than in T allele carriers, but this was not statistically significant (p>0.05) Three of the five patients that experienced implant loss and smoked, lost the implant earlier and had a higher average plaque and bleeding index. Conclusion: Based on our results, we can suggest that being an IL-1β positive genotype and a smoker can have an effect on implant losses. The study group should be enlarged to comment with statistically significant results. Cite this article as: Dizen F, G？rmü？ U, Ergen A, ünür M, ？plik ES, ？akmako？lu B, et al. Investigation of the IL-1 β Genotype and its Levels on Patients Treated with Osteointegrated Dental Implants. Experimed 2019; 9(1): 11-5