%0 Journal Article %T Investigation of the IL-1 ¦Â Genotype and its Levels on Patients Treated with Osteointegrated Dental Implants %A Bedia £¿akmako£¿lu %J - %D 2019 %X DOI: 10.26650/experimed.2019.19002 Objective: In our study, we aimed to investigate the relationship between the Interleukin-1¦Â (IL-1¦Â) +3953 gene polymorphism, the levels of this interleukin and smoking in osteointegrated dental implant losses. Materials and Methods: 56 patients with implants and 238 healthy control subjects were included in this study. PCR and RFLP methods was used to determine the IL-1¦Â +3953 gene polymorphisms. Serum IL-1¦Â levels were measured using ELISA. Results: The IL-1¦Â +3953 CC, TT and CT genotype frequencies for the controls and study cases were 61.2%, 10.1% ,43.6%, and 48.2%, 8.9% and 42.9%, respectively. IL-1¦Â +3953 T allele carriers increased more in the patient group (51.8%) compared to the control group (38.8%). These cases also had an increased plaque index, bleeding index, pocket deepness and serum IL-1¦Â levels, but none of them were statistically significant (p>0.05). Implant losses were more frequent in C allele carriers than in T allele carriers, but this was not statistically significant (p>0.05) Three of the five patients that experienced implant loss and smoked, lost the implant earlier and had a higher average plaque and bleeding index. Conclusion: Based on our results, we can suggest that being an IL-1¦Â positive genotype and a smoker can have an effect on implant losses. The study group should be enlarged to comment with statistically significant results. Cite this article as: Dizen F, G£¿rm¨¹£¿ U, Ergen A, ¨¹n¨¹r M, £¿plik ES, £¿akmako£¿lu B, et al. Investigation of the IL-1 ¦Â Genotype and its Levels on Patients Treated with Osteointegrated Dental Implants. Experimed 2019; 9(1): 11-5 %K IL-1¦Â +3953 %K implant %K interl£¿kin %K polimorfizm %U http://dergipark.org.tr/experimed/issue/44931/559453