PIPERIDINIUM 2-((5-(FURAN-2-YL)-4-PHENYL-4H-1,2,4-TRIAZOL)-3-YL) ACETATE FORCED DEGRADATION STUDY

Objective: Aim of the research to make forced degradation study of piperidinium 2-((5- (furan-2-yl)-4-phenyl-4H-1,2,4-triazol-3-yl) acetate in active pharmaceutical ingredient (API), 0.1% solution and 1% solution for injection. Influence of the sodium hydroxide, hydrochloride acid, 3% Н2О2, temperature, UV radiation on piperidine 2-((5-(furan-2-yl) -4-phenyl-4H-1,2,4-triazol-3-yl) acetate substance, 0.1% solution and 1% solution for injections was studied. Material and method: Agilent 1260 Infinity HPLC System. Agilent single-quadrupole mass spectrometer 6120. Result and discussion: Dependence of the quantitative content of the piperidinium 2-((5-(furan-2-yl)-4-phenyl-4H-1,2,4-triazol-3-yl) acetate from exposition time was determined. The composition of impurities formed under the action of an oxidizer was established (3%Н2О2). This is sulfoxide and sulfone corresponding to the API. The composition of impurities which were formed under the influence of UV radiation was proposed