%0 Journal Article
%T PIPERIDINIUM 2-((5-(FURAN-2-YL)-4-PHENYL-4H-1,2,4-TRIAZOL)-3-YL) ACETATE FORCED DEGRADATION STUDY
%A Borys Varynskyi
%J -
%D 2019
%X Objective: Aim of the research to make forced degradation study of piperidinium 2-((5- (furan-2-yl)-4-phenyl-4H-1,2,4-triazol-3-yl) acetate in active pharmaceutical ingredient (API), 0.1% solution and 1% solution for injection. Influence of the sodium hydroxide, hydrochloride acid, 3% §¯2§°2, temperature, UV radiation on piperidine 2-((5-(furan-2-yl) -4-phenyl-4H-1,2,4-triazol-3-yl) acetate substance, 0.1% solution and 1% solution for injections was studied. Material and method: Agilent 1260 Infinity HPLC System. Agilent single-quadrupole mass spectrometer 6120. Result and discussion: Dependence of the quantitative content of the piperidinium 2-((5-(furan-2-yl)-4-phenyl-4H-1,2,4-triazol-3-yl) acetate from exposition time was determined. The composition of impurities formed under the action of an oxidizer was established (3%§¯2§°2). This is sulfoxide and sulfone corresponding to the API. The composition of impurities which were formed under the influence of UV radiation was proposed
%K ESI k¨¹tle spektrometresi
%K triazoller
%K y¨¹ksek bas£¿n£¿l£¿ s£¿v£¿ kromatografisi
%K zorlanm£¿£¿ bozunma £¿al£¿£¿mas£¿
%U http://dergipark.org.tr/jfpanu/issue/45601/480073