129Xe Hyper-CEST/19F MRI Multimodal Imaging System for Sensitive and Selective Tumor Cells Detection

Heteronuclear MRI offers broad potential for specific detection and quantification of molecularly targeted agents in diagnosis and therapy planning or monitoring. Here we report a novel method for simultaneous acquisition of dual-nuclei hyper-CEST 129Xe and 19F tumor targeting MRI. 129Xe hyper-CEST MRI, 19F MRI and fluorescent imaging were integrated into PFOB nanoemulsion as a imaging system for sensitive and selective tumor cells detection. As the complement to 1H MRI, 129Xe and 19F signals can also provide efficient and precise anatomical localization of tumors