%0 Journal Article
%T 129Xe Hyper-CEST/19F MRI Multimodal Imaging System for Sensitive and Selective Tumor Cells Detection
%J -
%D 2019
%R https://doi.org/10.1021/acsabm.8b00635
%X Heteronuclear MRI offers broad potential for specific detection and quantification of molecularly targeted agents in diagnosis and therapy planning or monitoring. Here we report a novel method for simultaneous acquisition of dual-nuclei hyper-CEST 129Xe and 19F tumor targeting MRI. 129Xe hyper-CEST MRI, 19F MRI and fluorescent imaging were integrated into PFOB nanoemulsion as a imaging system for sensitive and selective tumor cells detection. As the complement to 1H MRI, 129Xe and 19F signals can also provide efficient and precise anatomical localization of tumors
%U https://pubs.acs.org/doi/10.1021/acsabm.8b00635