Myosin II in Cancer Cells Shapes the Immune Microenvironment

Tumor migration is driven by actomyosin contractility. A recent publication by Georgouli et al. ( Cell 2019;176:757–774) describes how crosstalk between the cell migration machinery and tumor-associated macrophages (TAMs) shapes the microenvironment to promote tumor growth. Indirectly targeting TAMs by inhibiting the motility of tumor cells could hinder metastatic spread