ACMSD: A Novel Target for Modulating NAD+ Homeostasis

NAD + has a pivotal role in regulating many biological processes. A recent study (Palzer et al., Cell Rep. 2018, 25;1359–1370) demonstrated that alpha-amino-beta-carboxy-muconate-semialdehyde decarboxylase (ACMSD) is a key regulator of NAD + metabolism and overexpression of human ACMSD leads to niacin dependency for NAD + biosynthesis in mice, providing important insights into human diseases associated with niacin/NAD + deficiency