%0 Journal Article
%T ACMSD: A Novel Target for Modulating NAD+ Homeostasis
%J -
%D 2019
%R https://doi.org/10.1016/j.tem.2019.02.002
%X NAD + has a pivotal role in regulating many biological processes. A recent study (Palzer et al., Cell Rep. 2018, 25;1359¨C1370) demonstrated that alpha-amino-beta-carboxy-muconate-semialdehyde decarboxylase (ACMSD) is a key regulator of NAD + metabolism and overexpression of human ACMSD leads to niacin dependency for NAD + biosynthesis in mice, providing important insights into human diseases associated with niacin/NAD + deficiency
%U https://www.cell.com/trends/endocrinology-metabolism/fulltext/S1043-2760(19)30026-8