Structural Basis for the Dual Substrate Specificity of DOCK7 Guanine Nucleotide Exchange Factor

？ Crystal structure of DOCK7 DHR-2 has been solved in complex with Cdc42 ？ Structural compatibility accounts for the dual specificity of DOCK7 for Rac and Cdc42 ？ MD simulations suggest a conformational change of DOCK7 DHR-2 in complex with Rac1 ？ Structure-based mutagenesis identified specificity determinants of DOCK