Structure of the UHRF1 Tandem Tudor Domain Bound to a Methylated Non-histone Protein, LIG1, Reveals Rules for Binding and Regulation

？ The crystal structure of UHRF1 TTD domain bound to the LIG1K126me3 was determined ？ Arg121 of LIG1 is a key residue for high-affinity binding to the TTD ？ Phosphorylation of LIG1T123 negatively regulates the interaction with UHRF1 ？ LIG1K126me3 binding changes UHRF1 structure from closed to ope